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Csnk2a1 Gene Detail
 Symbol
Name
ID
Csnk2a1
casein kinase 2, alpha 1 polypeptide
MGI:88543


Nomenclature History
Synonyms Csnk2a1-rs4
Genetic Map
Chromosome 2
Syntenic
 
Mapping data( 1)
Sequence Map
Chr2:152052575-152107588 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF300483
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000015858 VEGA Gene Model | MGI Sequence Detail 55014 C57BL/6J ± Kb
transcript NM_007788 RefSeq | MGI Sequence Detail 4208 C57BL/6
polypeptide Q60737 UniProt | EBI | MGI Sequence Detail 391 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes
All alleles(62) : Targeted, knock-out(1) Gene trapped(61)
Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development.
Polymorphisms SNPs within 2kb(117 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process protein amino acid autophosphorylation, protein amino acid phosphorylation...
Component protein kinase CK2 complex
Function ATP binding, beta-catenin binding...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (5)    Results (129)    Tissues (92)    Images (1)
Theiler Stages: 11,13,17,19,20,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 1   46
      RNA in situ 3   46
      Immunohistochemistry 1   37
cDNA source data(19)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(21) Primer pair(2) Antibodies(1)
Microarray probesets(8)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000074698
Consensus CDS Project CCDS16879.1
Entrez Gene 12995
VEGA Gene Model OTTMUSG00000015858
International Mouse Knockout Project Status Csnk2a1
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:2617 Yang-Feng TL et al., "Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit." Nucleic Acids Res 1991 Dec;19(25):7125-9
(Latest) J:147042 Maier B et al., "A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock." Genes Dev 2009 Mar 15;23(6):708-18
All references(25)
Other
accession IDs
MGD-MRK-2201, MGI:894650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory