Symbol
Name
ID
|
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(29)
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Alleles
and
phenotypes
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All alleles(7) :
Targeted, knock-out(2)
Targeted, other(3)
Gene trapped(2)
| Homozygotes for targeted null mutations exhibit growth retardation, neural tube defects, and developmental arrest at the 10-12 somite stage. Mutants die between embryonic days nine and ten. |
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Polymorphisms
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RFLP(3)
SNPs within 2kb(35 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (13 records)
Data Summary:
Assays (3)
Results (16)
Tissues (12)
Images (7)
Theiler Stages: 15,17,18,24,28
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Assay Type |
Assays |
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Results |
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RNA in situ |
2 |
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13 |
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Northern blot |
1 |
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3 |
cDNA source data(12)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(17)
Genomic(1)
cDNA(14)
Primer pair(1)
Other(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000980 |
SH2 motif |
| IPR001245 |
Tyrosine-protein kinase, catalytic domain |
| IPR001452 |
Src homology-3 domain |
| IPR008266 |
Tyrosine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR015778 |
Tyrosine-protein kinase, non-receptor Csk |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR020635 |
Tyrosine-protein kinase, subgroup, catalytic domain |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:1184
Armstrong E et al.,
"The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25."
Cytogenet Cell Genet 1992;60(2):119-20
(Latest)
J:148253
Kao TJ et al.,
"SRC family kinases are required for limb trajectory selection by spinal motor axons."
J Neurosci 2009 Apr 29;29(17):5690-700
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All references(48)
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Other
accession IDs
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MGD-MRK-2195, MGI:2143301
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