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Clu Gene Detail
 Symbol
Name
ID
Clu
clusterin
MGI:88423


Nomenclature History
Synonyms ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp-2, Sgp2, SP-40, Sugp-2, testosterone repressed prostate message-2
Genetic Map
Chromosome 14
28.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 17)

Sequence Map
Chr14:66587320-66600385 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Clu ± 2 cM)
Protein SuperFamily: clusterin
TreeFam: TF333030
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000032654 VEGA Gene Model | MGI Sequence Detail 13066 C57BL/6J ± Kb
transcript NM_013492 RefSeq | MGI Sequence Detail 1808 C57BL/6
polypeptide Q06890 UniProt | EBI | MGI Sequence Detail 448 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Gene trapped(2)
Homozygous mutation of this gene results in increased severity of experimentally-induced autoimmune myocarditis. Mutant hearts become pale and enlarged and exhibit 3-fold greater tissue injury compared to wild-type hearts.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(4) SNPs within 2kb(42 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Process cell death
Component extracellular region
External Resources: FuncBase
Expression Literature Summary: (18 records)
Data Summary: Assays (8)    Results (130)    Tissues (120)    Images (31)
Theiler Stages: 17,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 3   13
      RNA in situ 5   117
cDNA source data(572)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(585) Genomic(4) cDNA(575) Primer pair(4) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022037
DoTS DT.101190629, DT.101316252, DT.101316259, DT.101713458, DT.91337342
Consensus CDS Project CCDS36957.1
UniGene 200608
DFCI TC1573780, TC1661408
NIA Mouse Gene Index U015783
Entrez Gene 12759
VEGA Gene Model OTTMUSG00000032654
International Mouse Knockout Project Status Clu
Protein
domains
InterPro ID Description
IPR000753 Clusterin-like
IPR016014 Clusterin, N-terminal
IPR016015 Clusterin, C-terminal
IPR016016 Clusterin
Graphical View of Protein Domain Structure
References
(Earliest) J:17167 Jenne DE et al., "Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid." Proc Natl Acad Sci U S A 1989 Sep;86(18):7123-7
(Latest) J:151233 Trimarchi JM et al., "Identification of genes expressed preferentially in the developing peripheral margin of the optic cup." Dev Dyn 2009 Sep;238(9):2327-9
All references(76)
Other
accession IDs
MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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