Symbol
Name
ID
|
|
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Synonyms
|
Cf-2, Cf2, FII, prothrombin, thrombin
|
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Genetic Map
|
|
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Sequence Map
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Mammalian
homology
|
|
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Sequences
|
All sequences(18)
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Alleles
and
phenotypes
|
All alleles(6) :
Targeted, knock-out(2)
Targeted, other(1)
Gene trapped(3)
| Homozygotes for targeted null mutations exhibit defects in yolk sac vasculature, internal bleeding, tissue necrosis, and die in mid- to late-gestation, or rarely, a few days after birth. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(170 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (8 records)
Data Summary:
Assays (5)
Results (22)
Tissues (14)
Theiler Stages: 11,13,15,17,19,20,21,22,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
5 |
|
22 |
cDNA source data(96)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(102)
Genomic(4)
cDNA(96)
Primer pair(2)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000001 |
Kringle |
| IPR000294 |
Gamma-carboxyglutamic acid-rich (GLA) domain |
| IPR001254 |
Peptidase S1/S6, chymotrypsin/Hap |
| IPR001314 |
Peptidase S1A, chymotrypsin |
| IPR002383 |
Coagulation factor, Gla domain |
| IPR003966 |
Peptidase S1A, prothrombin/thrombin |
| IPR009003 |
Serine/cysteine peptidase, trypsin-like |
| IPR012051 |
Peptidase S1A, prothrombin |
| IPR013806 |
Kringle-like fold |
| IPR018056 |
Kringle, conserved site |
| IPR018059 |
Kringle, subgroup |
| IPR018114 |
Peptidase S1/S6, chymotrypsin/Hap, active site |
| IPR018992 |
Thrombin light chain |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:10794
Degen SJ et al.,
"Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2."
DNA Cell Biol 1990 Sep;9(7):487-98
(Latest)
J:152846
Szabo R et al.,
"Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice."
Development 2009 Aug;136(15):2653-63
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All references(26)
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Other
accession IDs
|
MGD-MRK-1946, MGD-MRK-1952
|
