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Cdk4 Gene Detail
 Symbol
Name
ID
Cdk4
cyclin-dependent kinase 4
MGI:88357

Nomenclature History
Synonyms Crk3, p34PSK-J3/cdk4
Genetic Map
Chromosome 10
cytoband D3
 
Mapping data( 2)
Sequence Map
Chr10:126500590-126504976 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF101022
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000030604 VEGA Gene Model | MGI Sequence Detail 4387 C57BL/6J ± Kb
transcript NM_009870 RefSeq | MGI Sequence Detail 1365 -
polypeptide P30285 UniProt | EBI | MGI Sequence Detail 303 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes 		All alleles(81) : Targeted, knock-out(4) Targeted, other(2) Gene trapped(75)
Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(35 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell division...
Component cyclin-dependent protein kinase holoenzyme complex, nucleus...
Function ATP binding, cyclin-dependent protein kinase activity...
External Resources: FuncBase
Expression Literature Summary: (45 records)
Data Summary: Assays (21)    Results (179)    Tissues (122)    Images (27)
Theiler Stages: 15,17,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 11   39
      RNA in situ 4   102
      Northern blot 6   38
cDNA source data(387)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(391) cDNA(389) Primer pair(1) Other(1) Antibodies(5)
Microarray probesets(4)
Other database
links
EC 2.7.11.22
Ensembl Gene Model ENSMUSG00000006728
Consensus CDS Project CCDS24226.1
UniGene 6839
DFCI TC1573184
NIA Mouse Gene Index U012134
Entrez Gene 12567
VEGA Gene Model OTTMUSG00000030604
International Mouse Knockout Project Status Cdk4
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:2804 Matsushime H et al., "Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins." Cell 1992 Oct 16;71(2):323-34
(Latest) J:156386 Adon AM et al., "Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells." Mol Cell Biol 2010 Feb;30(3):694-710
All references(119)
Other
accession IDs 		MGD-MRK-1884, MGD-MRK-2147, MGI:88504
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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