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Cd8b1 Gene Detail
 Symbol
Name
ID
Cd8b1
CD8 antigen, beta chain 1
MGI:88347

Nomenclature History
STS D6Nds3
Synonyms Ly-3, Ly-C, Lyt-3
Genetic Map
Chromosome 6
30.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 39)

Sequence Map
Chr6:71272806-71287445 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd8b1 ± 2 cM)
Protein SuperFamily: T-cell surface glycoprotein CD8 beta chain
TreeFam: TF338028
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12526 NCBI Gene Model | MGI Sequence Detail 14640 C57BL/6J ± Kb
transcript NM_009858 RefSeq | MGI Sequence Detail 1416 C57BL/6
polypeptide P10300 UniProt | EBI | MGI Sequence Detail 213 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(3)
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
Polymorphisms All PCR and RFLP(9) : PCR(6) RFLP(3) SNPs within 2kb(141 from dbSNP Build 128)   SNPs within 2kb including multiple locations(147)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process immune response
Component cell surface, external side of plasma membrane...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(15)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(27) Genomic(8) cDNA(16) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000053044
Consensus CDS Project CCDS39506.1
PDB 2ATP, 3B9K, 3DMM
Entrez Gene 12526
International Mouse Knockout Project Status Cd8b1
Protein
domains
InterPro ID Description
IPR003596 Immunoglobulin V-set, subgroup
IPR007110 Immunoglobulin-like
IPR013106 Immunoglobulin V-set
IPR013783 Immunoglobulin-like fold
Graphical View of Protein Domain Structure
References
(Earliest) J:13485 Green MC et al., "Locus order in LG XVII." Mouse News Lett 1968;39():28
(Latest) J:149450 Clarke RL et al., "A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction." Eur J Immunol 2009 Jun;39(6):1619-31
All references(90)
Other
accession IDs 		MGD-MRK-11970, MGD-MRK-12075, MGD-MRK-1873
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory