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Cd8a Gene Detail
 Symbol
Name
ID
Cd8a
CD8 antigen, alpha chain
MGI:88346

Nomenclature History
STS D6Mit16
Synonyms Ly-2, Ly-35, Ly-B, Lyt-2
Genetic Map
Chromosome 6
30.5 cM, cytoband C
Detailed Genetic Map ± 1 cM
 
Mapping data( 67)

Sequence Map
Chr6:71323542-71327075 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd8a ± 2 cM)
Protein SuperFamily: T-cell surface glycoprotein CD8 alpha chain
TreeFam: TF336070
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000053977 Ensembl Gene Model | MGI Sequence Detail 3534 C57BL/6J ± Kb
transcript NM_001081110 RefSeq | MGI Sequence Detail 3130 -
polypeptide P01731 UniProt | EBI | MGI Sequence Detail 247 Not Applicable
For the selected sequences
All sequences(40)
Alleles
and
phenotypes 		All alleles(11) : Targeted, knock-out(10) Targeted, other(1)
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
Polymorphisms PCR(1) SNPs within 2kb(47 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell surface receptor linked signal transduction, cytotoxic T cell differentiation...
Component cell surface, external side of plasma membrane...
Function protein binding, protein homodimerization activity...
External Resources: FuncBase
Expression Literature Summary: (9 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(35)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(57) Genomic(18) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000053977
DoTS DT.101721974, DT.101724847, DT.528549
Consensus CDS Project CCDS39507.1
UniGene 1858
PDB 1BQH, 1NEZ, 2ARJ, 2ATP, 3B9K, 3DMM
DFCI TC1580454, TC1587101
NIA Mouse Gene Index U007018
Entrez Gene 12525
International Mouse Knockout Project Status Cd8a
Protein
domains
InterPro ID Description
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR013151 Immunoglobulin
IPR013783 Immunoglobulin-like fold
IPR015468 CD8 alpha subunit
Graphical View of Protein Domain Structure
References
(Earliest) J:5073 Boyse EA et al., "Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse." Proc R Soc Lond B Biol Sci 1968 Jun 11;170(19):175-93
(Latest) J:155104 Nakanishi Y et al., "CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help." Nature 2009 Nov 26;462(7272):510-3
All references(340)
Other
accession IDs 		MGD-MRK-11958, MGD-MRK-11976, MGD-MRK-12074, MGD-MRK-1872, MGI:2141733
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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