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Cd3e Gene Detail
 Symbol
Name
ID
Cd3e
CD3 antigen, epsilon polypeptide
MGI:88332

Nomenclature History
Synonyms CD3, CD3epsilon, T3e
Genetic Map
Chromosome 9
26.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 8)

Sequence Map
Chr9:44806826-44817673 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd3e ± 2 cM)
Protein SuperFamily: T-cell surface glycoprotein CD3 delta chain
TreeFam: TF335892
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016712 VEGA Gene Model | MGI Sequence Detail 10848 C57BL/6J ± Kb
transcript NM_007648 RefSeq | MGI Sequence Detail 1436 C57BL/6
polypeptide P22646 UniProt | EBI | MGI Sequence Detail 189 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes 		All alleles(5) : Targeted, knock-out(4) Chemically induced(1)
Mice homozygous null for this mutation lack peripherial T cells and have a block of thymocyte development at the DN3 stage.
Polymorphisms RFLP(3) SNPs within 2kb(95 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell surface receptor linked signal transduction, induction of apoptosis by extracellular signals...
Component alpha-beta T cell receptor complex, external side of plasma membrane...
Function protein binding, receptor activity...
External Resources: FuncBase
Expression Literature Summary: (20 records)
Data Summary: Assays (4)    Results (16)    Tissues (11)    Images (6)
Theiler Stages: 16,20,22,24,28
  Assay Type Assays   Results
      RT-PCR 1   8
      RNA in situ 2   6
      Immunohistochemistry 1   2
cDNA source data(19)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(37) Genomic(10) cDNA(23) Primer pair(1) Other(3) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000032093
DoTS DT.489703, DT.489704
Consensus CDS Project CCDS23125.1
UniGene 210361
PDB 1JBJ, 1XMW, 2K4F
DFCI TC1588586, TC1598036
NIA Mouse Gene Index U030791
Entrez Gene 12501
VEGA Gene Model OTTMUSG00000016712
International Mouse Knockout Project Status Cd3e
Protein
domains
InterPro ID Description
IPR003110 Phosphorylated immunoreceptor signaling ITAM
IPR003598 Immunoglobulin subtype 2
IPR007110 Immunoglobulin-like
IPR013151 Immunoglobulin
IPR013783 Immunoglobulin-like fold
IPR015477 CD3 epsilon chain
Graphical View of Protein Domain Structure
References
(Earliest) J:8304 Gold DP et al., "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex [published erratum appears in Nature 1986 Dec 18-31;324(6098):702]" Nature 1986 May 22-28;321(6068):431-4
(Latest) J:155493 Taillardet M et al., "The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells." Blood 2009 Nov 12;114(20):4432-40
All references(147)
Other
accession IDs 		MGD-MRK-14697, MGD-MRK-1853, MGI:2143086
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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