Symbol
Name
ID
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Synonyms
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beta catenin, beta-catenin, Catnb
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Genetic Map
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Sequence Map
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Mammalian homology
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Sequences
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All sequences(68)
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Alleles and phenotypes
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All alleles(20) :
Targeted, knock-out(3)
Targeted, other(9)
Gene trapped(8)
| Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E 7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinalcord size anomalies, etc. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
Phenotype Images (2)
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Polymorphisms
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PCR(1)
SNPs within 2kb(61 from dbSNP Build 128)
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Gene Ontology (GO) classifications
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Expression
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Literature Summary: (322 records)
Data Summary:
Assays (37)
Results (348)
Tissues (210)
Images (79)
Theiler Stages: 1,2,3,4,5,9,15,17,19,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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Western blot |
6 |
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31 |
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RT-PCR |
7 |
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130 |
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In situ reporter (knock in) |
1 |
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3 |
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RNA in situ |
5 |
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122 |
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Immunohistochemistry |
18 |
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62 |
cDNA source data(967)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
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Molecular reagents
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All nucleic(979)
cDNA(969)
Primer pair(9)
Other(1)
Antibodies(12)
Microarray probesets(4)
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Other database links
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| Ensembl Gene Model |
ENSMUSG00000006932 |
| DoTS |
DT.101138386, DT.101399058, DT.101399074, DT.102541092, DT.496455, DT.55189223, DT.94216387, DT.97365184, DT.97380877 |
| Consensus CDS Project |
CCDS23630.1 |
| UniGene |
291928 |
| PDB |
1DOW, 1I7W, 1I7X, 1JPP, 1M1E, 1V18, 2BCT, 3BCT |
| DFCI |
TC1573680, TC1649267 |
| NIA Mouse Gene Index |
U011162 |
| Entrez Gene |
12387 |
| VEGA Gene Model |
OTTMUSG00000016490 |
| International Mouse Knockout Project Status |
Ctnnb1 |
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Protein domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:37373
Ozawa M et al.,
"The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species."
EMBO J 1989 Jun;8(6):1711-7
(Latest)
J:155731
Held MA et al.,
"Characterization of melanoma cells capable of propagating tumors from a single cell."
Cancer Res 2010 Jan 1;70(1):388-97
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All references(596)
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Other accession IDs
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MGD-MRK-1775
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