Symbol
Name
ID
|
|
|
Synonyms
|
beta catenin, beta-catenin, Catnb
|
|
Genetic Map
|
|
|
Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(68)
|
Alleles
and
phenotypes
|
All alleles(20) :
Targeted, knock-out(3)
Targeted, other(9)
Gene trapped(8)
| Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E 7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinalcord size anomalies, etc. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
Phenotype Images (2)
|
|
Polymorphisms
|
PCR(1)
SNPs within 2kb(61 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (306 records)
Data Summary:
Assays (37)
Results (348)
Tissues (210)
Images (79)
Theiler Stages: 1,2,3,4,5,9,15,17,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
6 |
|
31 |
| |
RT-PCR |
7 |
|
130 |
| |
In situ reporter (knock in) |
1 |
|
3 |
| |
RNA in situ |
5 |
|
122 |
| |
Immunohistochemistry |
18 |
|
62 |
cDNA source data(967)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(978)
cDNA(969)
Primer pair(8)
Other(1)
Antibodies(12)
Microarray probesets(4)
|
Other database
links
|
| Ensembl Gene Model |
ENSMUSG00000006932 |
| DoTS |
DT.101138386, DT.101399058, DT.101399074, DT.102541092, DT.496455, DT.55189223, DT.94216387, DT.97365184, DT.97380877 |
| UniGene |
291928 |
| PDB |
1DOW, 1I7W, 1I7X, 1JPP, 1M1E, 1V18, 2BCT, 3BCT |
| DFCI |
TC1573680, TC1649267 |
| NIA Mouse Gene Index |
U011162 |
| Entrez Gene |
12387 |
| VEGA Gene Model |
OTTMUSG00000016490 |
| International Mouse Knockout Project Status |
Ctnnb1 |
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:37373
Ozawa M et al.,
"The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species."
EMBO J 1989 Jun;8(6):1711-7
(Latest)
J:154227
Feigenson K et al.,
"Wnt signaling is sufficient to perturb oligodendrocyte maturation."
Mol Cell Neurosci 2009 Nov;42(3):255-65
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All references(571)
|
Other
accession IDs
|
MGD-MRK-1775
|
|
