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Ctnnb1 Gene Detail
 Symbol
Name
ID
Ctnnb1
catenin (cadherin associated protein), beta 1
MGI:88276

Nomenclature History
Synonyms beta catenin, beta-catenin, Catnb
Genetic Map
Chromosome 9
72.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr9:120838334-120869625 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ctnnb1 ± 2 cM)
Protein SuperFamily: beta-catenin/plakoglobin
TreeFam: TF317997
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016490 VEGA Gene Model | MGI Sequence Detail 31292 C57BL/6J ± Kb
transcript NM_007614 RefSeq | MGI Sequence Detail 3640 C57BL/6
polypeptide Q02248 UniProt | EBI | MGI Sequence Detail 781 Not Applicable
For the selected sequences
All sequences(68)
Alleles
and
phenotypes 		All alleles(20) : Targeted, knock-out(3) Targeted, other(9) Gene trapped(8)
Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E 7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinalcord size anomalies, etc.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (2)  
Polymorphisms PCR(1) SNPs within 2kb(61 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (137 annotations)
Process anterior/posterior axis specification, apoptosis...
Component adherens junction, apical junction complex...
Function alpha-catenin binding, binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (322 records)
Data Summary: Assays (37)    Results (348)    Tissues (210)    Images (79)
Theiler Stages: 1,2,3,4,5,9,15,17,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 6   31
      RT-PCR 7   130
      In situ reporter (knock in) 1   3
      RNA in situ 5   122
      Immunohistochemistry 18   62
cDNA source data(967)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(979) cDNA(969) Primer pair(9) Other(1) Antibodies(12)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000006932
DoTS DT.101138386, DT.101399058, DT.101399074, DT.102541092, DT.496455, DT.55189223, DT.94216387, DT.97365184, DT.97380877
Consensus CDS Project CCDS23630.1
UniGene 291928
PDB 1DOW, 1I7W, 1I7X, 1JPP, 1M1E, 1V18, 2BCT, 3BCT
DFCI TC1573680, TC1649267
NIA Mouse Gene Index U011162
Entrez Gene 12387
VEGA Gene Model OTTMUSG00000016490
International Mouse Knockout Project Status Ctnnb1
Protein
domains
InterPro ID Description
IPR000225 Armadillo
IPR011989 Armadillo-like helical
IPR013284 Beta-catenin
IPR016024 Armadillo-type fold
Graphical View of Protein Domain Structure
References
(Earliest) J:37373 Ozawa M et al., "The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species." EMBO J 1989 Jun;8(6):1711-7
(Latest) J:155731 Held MA et al., "Characterization of melanoma cells capable of propagating tumors from a single cell." Cancer Res 2010 Jan 1;70(1):388-97
All references(596)
Other
accession IDs 		MGD-MRK-1775
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory