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Cat Gene Detail
 Symbol
Name
ID
Cat
catalase
MGI:88271


Nomenclature History
Synonyms Cas-1, Cas1, Cs-1
Genetic Map
Chromosome 2
57.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 34)

Sequence Map
Chr2:103294006-103325317 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cat ± 2 cM)
Protein SuperFamily: catalase
TreeFam: TF300540
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000014875 VEGA Gene Model | MGI Sequence Detail 31312 C57BL/6J ± Kb
transcript NM_009804 RefSeq | MGI Sequence Detail 2551 C57BL/6
polypeptide P24270 UniProt | EBI | MGI Sequence Detail 527 Not Applicable
For the selected sequences
All sequences(44)
Alleles
and
phenotypes
All alleles(8) : Targeted, knock-out(1) Gene trapped(1) Radiation induced(5) Other(1)
Mice homozygous for disruptions in this gene display a generally normal phenotype although subtle abnormalities do occur in mitochondrial respiration.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(6) SNPs within 2kb(210 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(28)
Process aerobic respiration, cholesterol metabolic process...
Component mitochondrion, peroxisomal membrane...
Function aminoacylase activity, catalase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (9 records)
Data Summary: Assays (5)    Results (15)    Tissues (8)
Theiler Stages: 4,22,26,28
  Assay Type Assays   Results
      Western blot 1   6
      RT-PCR 3   7
      Immunohistochemistry 1   2
cDNA source data(298)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(340) Genomic(35) cDNA(303) Primer pair(1) Other(1) Antibodies(2)
Microarray probesets(3)
Pathways
removal of superoxide radicals
Other database
links
EC 1.11.1.6
Ensembl Gene Model ENSMUSG00000027187
DoTS DT.101198673, DT.87073214
UniGene 4215
DFCI TC1577923, TC1635154
NIA Mouse Gene Index U023085
Entrez Gene 12359
VEGA Gene Model OTTMUSG00000014875
International Mouse Knockout Project Status Cat
Protein
domains
InterPro ID Description
IPR002226 Catalase
IPR010582 Catalase-related immune responsive
IPR011614 Catalase, N-terminal
IPR018028 Catalase related subgroup
IPR020835 Catalase-like domain, haem-dependent
Graphical View of Protein Domain Structure
References
(Earliest) J:5015 Feinstein RN et al., "Acatalasemic and hypocatalasemic mouse mutants." Genetics 1966 May;53(5):923-33
(Latest) J:150363 Chung YW et al., "Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death." Mol Cells 2009 May;27(5):609-13
All references(93)
Other
accession IDs
MGD-MRK-1765, MGD-MRK-1766, MGD-MRK-2185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory