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Camk2b Gene Detail
 Symbol
Name
ID
Camk2b
calcium/calmodulin-dependent protein kinase II, beta
MGI:88257

Nomenclature History
Synonyms CaMK II
Genetic Map
Chromosome 11
0.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr11:5869647-5966365 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Camk2b ± 2 cM)
Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
TreeFam: TF315229
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005105 VEGA Gene Model | MGI Sequence Detail 96719 C57BL/6J ± Kb
transcript NM_007595 RefSeq | MGI Sequence Detail 3935 C57BL/6
polypeptide P28652 UniProt | EBI | MGI Sequence Detail 542 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes 		All alleles(13) : Targeted, knock-out(1) Gene trapped(12)
Mice homozygous for a knock-out allele exhibit reversal of plasticity direction at parallel fiber-Purkinje cell synapses.
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(231 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process calcium ion transport, G1/S transition of mitotic cell cycle...
Component calcium- and calmodulin-dependent protein kinase complex
Function ATP binding, calmodulin binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(52)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(59) Genomic(4) cDNA(53) Primer pair(2) Antibodies(2)
Microarray probesets(2)
Other database
links
EC 2.7.11.17
Ensembl Gene Model ENSMUSG00000057897
DoTS DT.101148087, DT.101264232, DT.110526260, DT.40169561, DT.94238857, DT.97407095
Consensus CDS Project CCDS24411.1
UniGene 439733
DFCI TC1576025, TC1587035, TC1593226, TC1598554, TC1617955, TC1689622
NIA Mouse Gene Index U032479
Entrez Gene 12323
VEGA Gene Model OTTMUSG00000005105
International Mouse Knockout Project Status Camk2b
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR015742 Calcium/calmodulin-dependent protein kinase II isoform
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR020636 Calcium/calmodulin-dependent protein kinase-like
Graphical View of Protein Domain Structure
References
(Earliest) J:1487 Karls U et al., "Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant." Mol Cell Biol 1992 Aug;12(8):3644-52
(Latest) J:152575 van Woerden GM et al., "betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses." Nat Neurosci 2009 Jul;12(7):823-5
All references(28)
Other
accession IDs 		MGD-MRK-1744
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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