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Camk2a Gene Detail
 Symbol
Name
ID
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
MGI:88256

Nomenclature History
Synonyms alpha-CaMKII, CaMKII, mKIAA0968
Genetic Map
Chromosome 18
33.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr18:61085272-61147806 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Camk2a ± 2 cM)
Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
TreeFam: TF315229
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016302 VEGA Gene Model | MGI Sequence Detail 62535 C57BL/6J ± Kb
transcript NM_177407 RefSeq | MGI Sequence Detail 4966 C57BL/6
polypeptide P11798 UniProt | EBI | MGI Sequence Detail 478 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes 		All alleles(34) : Targeted, knock-out(3) Targeted, other(6) Gene trapped(25)
Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.
Polymorphisms RFLP(2) SNPs within 2kb(386 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process calcium ion transport, G1/S transition of mitotic cell cycle...
Component calcium- and calmodulin-dependent protein kinase complex, cell junction...
Function ATP binding, calmodulin binding...
External Resources: FuncBase
Expression Literature Summary: (12 records)
Data Summary: Assays (4)    Results (57)    Tissues (53)    Images (6)
Theiler Stages: 1,2,20,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   50
      RNA in situ 1   2
      Immunohistochemistry 1   5
cDNA source data(27)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(32) Genomic(1) cDNA(29) Primer pair(2) Antibodies(3)
Microarray probesets(2)
Other database
links
EC 2.7.11.17
Ensembl Gene Model ENSMUSG00000024617
DoTS DT.101299628, DT.40167149, DT.55281964, DT.91327836
Consensus CDS Project CCDS29276.1, CCDS29277.1
UniGene 131530
PDB 1HKX
DFCI TC1581606, TC1593090, TC1679395, TC1684806
NIA Mouse Gene Index U018785
Entrez Gene 12322
VEGA Gene Model OTTMUSG00000016302
International Mouse Knockout Project Status Camk2a
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR015742 Calcium/calmodulin-dependent protein kinase II isoform
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR020636 Calcium/calmodulin-dependent protein kinase-like
Graphical View of Protein Domain Structure
References
(Earliest) J:9840 Hanley RM et al., "Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain." Nucleic Acids Res 1989 May 25;17(10):3992
(Latest) J:154426 Sametsky EA et al., "Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation." Neurobiol Learn Mem 2009 Jul;92(1):120-3
All references(91)
Other
accession IDs 		MGD-MRK-1743, MGI:2147420
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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