Symbol
Name
ID
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Synonyms
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alpha-CaMKII, CaMKII, mKIAA0968
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(26)
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Alleles
and
phenotypes
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All alleles(34) :
Targeted, knock-out(3)
Targeted, other(6)
Gene trapped(25)
| Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(386 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (12 records)
Data Summary:
Assays (4)
Results (57)
Tissues (53)
Images (6)
Theiler Stages: 1,2,20,22,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
50 |
| |
RNA in situ |
1 |
|
2 |
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Immunohistochemistry |
1 |
|
5 |
cDNA source data(27)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(32)
Genomic(1)
cDNA(29)
Primer pair(2)
Antibodies(3)
Microarray probesets(2)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR013543 |
Calcium/calmodulin-dependent protein kinase II, association-domain |
| IPR015742 |
Calcium/calmodulin-dependent protein kinase II isoform |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:9840
Hanley RM et al.,
"Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain."
Nucleic Acids Res 1989 May 25;17(10):3992
(Latest)
J:150467
Xie W et al.,
"Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms."
Neurobiol Dis 2009 Jul;35(1):52-62
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All references(87)
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Other
accession IDs
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MGD-MRK-1743, MGI:2147420
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