Symbol
Name
ID
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Synonyms
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Bruton's tyrosine kinase, X-linked immune deficiency, xid
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(37)
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Alleles
and
phenotypes
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All alleles(733) :
Targeted, knock-out(1)
Targeted, other(2)
Gene trapped(729)
Spontaneous(1)
| Mutants have immune defects including reduced B cell numbers, serum immunoglobulin deficiencies, and defective responses to B cell activators and thymus-independent antigens. B-1 B cells are absent in these mice. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (2)
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Polymorphisms
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RFLP(3)
SNPs within 2kb(165 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (2 records)
Data Summary:
Assays (2)
Results (2)
Tissues (2)
Images (2)
Theiler Stages: 22,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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1 |
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RNA in situ |
1 |
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1 |
cDNA source data(30)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(53)
Genomic(18)
cDNA(32)
Primer pair(2)
Other(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:34558
Scher I et al.,
"X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect."
J Exp Med 1975 Sep 1;142(3):637-50
(Latest)
J:154200
Schmidt U et al.,
"The protein tyrosine kinase Tec regulates mast cell function."
Eur J Immunol 2009 Aug 17;39(11):3228-3238
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All references(250)
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Other
accession IDs
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MGD-MRK-15473, MGD-MRK-1683, MGI:2147899
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