Symbol
Name
ID
|
|
|
STS
|
D7Mit57
|
|
Genetic Map
|
|
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Sequence Map
|
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Mammalian
homology
|
|
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Sequences
|
All sequences(47)
|
Alleles
and
phenotypes
|
All alleles(32) :
Targeted, knock-out(3)
Targeted, other(9)
Gene trapped(18)
Transgenic(1)
Spontaneous(1)
| Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions. |
Associated Human Diseases (4)
Alleles Annotated to Human Diseases (4)
Phenotype Images (10)
|
|
Polymorphisms
|
RFLP(8)
SNPs within 2kb(39 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (23 records)
Data Summary:
Assays (14)
Results (176)
Tissues (145)
Images (29)
Theiler Stages: 11,13,15,22,23,24,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
48 |
| |
RNA in situ |
3 |
|
98 |
| |
Northern blot |
9 |
|
30 |
cDNA source data(28)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(38)
Genomic(2)
cDNA(28)
Primer pair(2)
Other(6)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000074 |
Apolipoprotein A1/A4/E |
| IPR013326 |
Apolipoprotein/apolipophorin |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:5183
Forsthoefel PF et al.,
"Linkage relationships of Strong's luxoid gene in the mouse."
J Hered 1970 Mar-Apr;61(2):64-6
(Latest)
J:154141
Zhou C et al.,
"Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apolipoprotein E deficient mice."
J Lipid Res 2009 May 12;():
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All references(1022)
|
Other
accession IDs
|
MGD-MRK-1376, MGI:2141887
|
