Symbol
Name
ID
|
|
|
Synonyms
|
apob-100, apob-48
|
|
Genetic Map
|
|
|
Sequence Map
|
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Mammalian
homology
|
|
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Sequences
|
All sequences(37)
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Alleles
and
phenotypes
|
All alleles(11) :
Targeted, knock-out(4)
Targeted, other(7)
| Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (9)
Phenotype Images (3)
|
|
Polymorphisms
|
RFLP(6)
SNPs within 2kb(35 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (3)
Results (26)
Tissues (13)
Images (2)
Theiler Stages: 11,17,21,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
5 |
| |
RT-PCR |
1 |
|
8 |
| |
RNase protection |
1 |
|
13 |
cDNA source data(52)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(64)
Genomic(4)
cDNA(58)
Primer pair(2)
Antibodies(1)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR001747 |
Lipid transport protein, N-terminal |
| IPR009454 |
Lipid transport, open beta-sheet |
| IPR011030 |
Vitellinogen, superhelical |
| IPR015255 |
Vitellinogen, open beta-sheet |
| IPR015816 |
Vitellinogen, beta-sheet N-terminal |
| IPR015817 |
Vitellinogen, open beta-sheet, subdomain 1 |
| IPR015819 |
Lipid transport protein, beta-sheet shell |
|
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References
|
(Earliest)
J:24996
Mahley RW et al.,
"Plasma lipoproteins: apolipoprotein structure and function."
J Lipid Res 1984 Dec 1;25(12):1277-94
(Latest)
J:151211
Xie Y et al.,
"Decreased Expression of Cholesterol 7{alpha}-Hydroxylase and Altered Bile Acid Metabolism in Apobec-1-/- Mice Lead to Increased Gallstone Susceptibility."
J Biol Chem 2009 Jun 19;284(25):16860-71
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All references(108)
|
Other
accession IDs
|
MGD-MRK-1370, MGI:2144785
|
