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Apc Gene Detail
 Symbol
Name
ID
Apc
adenomatosis polyposis coli
MGI:88039

Nomenclature History
Synonyms CC1, Min
Genetic Map
Chromosome 18
15.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 20)

Sequence Map
Chr18:34380638-34479735 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Apc ± 2 cM)
Protein SuperFamily: adenomatous polyposis coli protein
TreeFam: TF106496
Sequences
Representative Sequences Length Strain/Species Flank
genomic 11789 NCBI Gene Model | MGI Sequence Detail 99098 C57BL/6J ± Kb
transcript NM_007462 RefSeq | MGI Sequence Detail 12453 C57BL/6
polypeptide Q61315 UniProt | EBI | MGI Sequence Detail 2845 Not Applicable
For the selected sequences
All sequences(56)
Alleles
and
phenotypes 		All alleles(66) : Targeted, knock-out(9) Targeted, other(11) Gene trapped(45) Chemically induced(1)
Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence.
Associated Human Diseases (6)   Alleles Annotated to Human Diseases (5)   Phenotype Images (8)  
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(460 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (128 annotations)
Process anterior/posterior pattern formation, axis specification...
Component axon part, cell junction...
Function beta-catenin binding, binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (19 records)
Data Summary: Assays (3)    Results (59)    Tissues (50)    Images (10)
Theiler Stages: 20,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   47
      RNA in situ 1   12
cDNA source data(24)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(36) Genomic(1) cDNA(28) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000005871
DoTS DT.101156961, DT.101187621, DT.485678, DT.91297212, DT.91401983, DT.94179295, DT.94237223, DT.94359608
Consensus CDS Project CCDS29125.1
PDB 1VJ6
DFCI TC1588179, TC1592394, TC1597237, TC1602812, TC1612444, TC1631288, TC1651499, TC1678384
NIA Mouse Gene Index U018534, U043657, U052693
Entrez Gene 11789
International Mouse Knockout Project Status Apc
Protein
domains
InterPro ID Description
IPR000225 Armadillo
IPR009223 APC cysteine-rich
IPR009224 SAMP
IPR009232 EB-1 binding
IPR009234 APC basic
IPR009240 APC 15 residue
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
Graphical View of Protein Domain Structure
References
(Earliest) J:103 Lane PW et al., "Mahogany, a recessive color mutation in linkage group V of the mouse" J Hered 1960;51():228-230
(Latest) J:156407 Evans PM et al., "KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin." Mol Cell Biol 2010 Jan;30(2):372-81
All references(624)
Other
accession IDs 		MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory