Symbol
Name
ID
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Synonyms
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CC1, Min
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(56)
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Alleles
and
phenotypes
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All alleles(60) :
Targeted, knock-out(9)
Targeted, other(11)
Gene trapped(39)
Chemically induced(1)
| Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence. |
Associated Human Diseases (5)
Alleles Annotated to Human Diseases (5)
Phenotype Images (8)
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Polymorphisms
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All PCR and RFLP(5) :
PCR(2)
RFLP(3)
SNPs within 2kb(460 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (16 records)
Data Summary:
Assays (3)
Results (59)
Tissues (50)
Images (10)
Theiler Stages: 20,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
47 |
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RNA in situ |
1 |
|
12 |
cDNA source data(23)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(35)
Genomic(1)
cDNA(27)
Primer pair(6)
Other(1)
Microarray probesets(4)
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Other database
links
|
| Ensembl Gene Model |
ENSMUSG00000005871 |
| DoTS |
DT.101156961, DT.101187621, DT.485678, DT.91297212, DT.91401983, DT.94179295, DT.94237223, DT.94359608 |
| PDB |
1VJ6 |
| DFCI |
TC1588179, TC1592394, TC1597237, TC1602812, TC1612444, TC1631288, TC1651499, TC1678384 |
| NIA Mouse Gene Index |
U018534, U043657, U052693 |
| Entrez Gene |
11789 |
| International Mouse Knockout Project Status |
Apc |
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
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References
|
(Earliest)
J:103
Lane PW et al.,
"Mahogany, a recessive color mutation in linkage group V of the mouse"
J Hered 1960;51():228-230
(Latest)
J:154131
Wu S et al.,
"A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses."
Nat Med 2009 Sep;15(9):1016-22
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All references(613)
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Other
accession IDs
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MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352
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