Symbol
Name
ID
|
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(39)
|
Alleles
and
phenotypes
|
All alleles(8) :
Targeted, knock-out(5)
Targeted, other(3)
| Homozygous mutants show retarded postnatal development, tremors, impaired righting response, delayed maturation of external ear, failure of eyelids to open, and die by 3-wk. of age. Mutants are highly sensitive to butyrylcholinesterase inhibitor toxicity. |
|
|
Polymorphisms
|
RFLP(1)
SNPs within 2kb(18 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (49 records)
Data Summary:
Assays (11)
Results (99)
Tissues (52)
Images (1)
Theiler Stages: 19,21,23,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
8 |
|
86 |
| |
Immunohistochemistry |
1 |
|
3 |
| |
RNase protection |
2 |
|
10 |
cDNA source data(23)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(34)
Genomic(7)
cDNA(24)
Primer pair(3)
Antibodies(1)
Microarray probesets(2)
|
Other database
links
|
| EC |
3.1.1.7 |
| Ensembl Gene Model |
ENSMUSG00000023328 |
| PDB |
1C2B, 1C2O, 1J06, 1J07, 1KU6, 1MAA, 1MAH, 1N5M, 1N5R, 1Q83, 1Q84, 2C0P, 2C0Q, 2GYU, 2GYV, 2GYW, 2H9Y, 2HA0, 2HA2, 2HA3, 2HA4, 2HA5, 2HA6, 2HA7, 2JEY, 2JEZ, 2JF0, 2JGE, 2JGF, 2JGG, 2JGH, 2JGI, 2JGJ, 2JGK, 2JGL, 2JGM, 2WHP, 2WHQ, 2WHR, 2WLS, 3DL4, 3DL7 |
| DFCI |
TC1582401, TC1607531, TC1708696, TC1719066 |
| NIA Mouse Gene Index |
U006316 |
| Entrez Gene |
11423 |
| VEGA Gene Model |
OTTMUSG00000021643 |
| International Mouse Knockout Project Status |
Ache |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000997 |
Cholinesterase |
| IPR002018 |
Carboxylesterase, type B |
| IPR014788 |
Acetylcholinesterase, tetramerisation |
| IPR019819 |
Carboxylesterase type B, conserved site |
| IPR019826 |
Carboxylesterase type B, active site |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:13986
Sweet HO,
"Wasted linkage"
Mouse News Lett 1984;71():31
(Latest)
J:153967
Espallergues J et al.,
"Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs."
Behav Brain Res 2010 Jan 20;206(2):263-73
|
All references(114)
|
Other
accession IDs
|
MGD-MRK-1035
|
|
