About   Help   FAQ
Tour our new Quick Search
Acat2 Gene Detail
 Symbol
Name
ID
Acat2
acetyl-Coenzyme A acetyltransferase 2
MGI:87871

Nomenclature History
Synonyms Tcp-1x, Tcp1-rs1
Genetic Map
Chromosome 17
7.55 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr17:13135756-13153613 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Acat2 ± 2 cM)
Protein SuperFamily: acetyl-CoA acetyltransferase
TreeFam: TF300650
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000028085 VEGA Gene Model | MGI Sequence Detail 17858 C57BL/6J ± Kb
transcript NM_009338 RefSeq | MGI Sequence Detail 2076 C57BL/6
polypeptide Q8CAY6 UniProt | EBI | MGI Sequence Detail 397 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes 		All alleles(1) : Gene trapped(1)
Polymorphisms RFLP(2) SNPs within 2kb(65 from dbSNP Build 128)   SNPs within 2kb including multiple locations(117)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process metabolic process
Component cytoplasm, mitochondrion...
Function acetyl-CoA C-acetyltransferase activity, acyltransferase activity...
External Resources: FuncBase
Expression cDNA source data(176)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(183) Genomic(5) cDNA(178)
Microarray probesets(1)
Pathways
acetoacetate degradation (to acetyl CoA)
2-methylbutyrate biosynthesis
glutaryl-CoA degradation
3-hydroxypropionate/4-hydroxybutyrate cycle
mevalonate pathway
isoleucine degradation
ketone oxidation
ketogenesis
superpathway of cholesterol biosynthesis
tryptophan degradation III (eukaryotic)
Other database
links
EC 2.3.1.9
Ensembl Gene Model ENSMUSG00000023832
DoTS DT.101720591, DT.536009, DT.91482569
Consensus CDS Project CCDS37437.1
UniGene 439711
Entrez Gene 110460
VEGA Gene Model OTTMUSG00000028085
International Mouse Knockout Project Status Acat2
Protein
domains
InterPro ID Description
IPR002155 Thiolase
IPR016038 Thiolase-like, subgroup
IPR016039 Thiolase-like
IPR020610 Thiolase, active site
IPR020613 Thiolase, conserved site
IPR020616 Thiolase, N-terminal
IPR020617 Thiolase, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:8190 Willison KR et al., "Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1." Cell 1986 Mar 14;44(5):727-38
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(15)
Other
accession IDs 		MGD-MRK-1029, MGD-MRK-14817, MGD-MRK-14828, MGI:2147098, MGI:98537
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory