About   Help   FAQ
Tour our new Quick Search
Acadm Gene Detail
 Symbol
Name
ID
Acadm
acyl-Coenzyme A dehydrogenase, medium chain
MGI:87867

Nomenclature History
Synonyms MCAD
Genetic Map
Chromosome 3
73.6 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr3:153585321-153607596 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Acadm ± 2 cM)
Protein SuperFamily: acyl-CoA dehydrogenase
TreeFam: TF105020
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000031346 VEGA Gene Model | MGI Sequence Detail 22276 C57BL/6J ± Kb
transcript NM_007382 RefSeq | MGI Sequence Detail 1845 C57BL/6
polypeptide P45952 UniProt | EBI | MGI Sequence Detail 421 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes 		All alleles(41) : Targeted, knock-out(1) Gene trapped(40)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (1)  
Polymorphisms RFLP(4) SNPs within 2kb(103 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cardiac muscle cell differentiation, carnitine metabolic process...
Component mitochondrion
Function acyl-CoA dehydrogenase activity, FAD binding...
External Resources: FuncBase
Expression Literature Summary: (10 records)
Data Summary: Assays (6)    Results (120)    Tissues (105)    Images (26)
Theiler Stages: 21,22,24,26,28
  Assay Type Assays   Results
      RT-PCR 1   6
      RNA in situ 2   97
      Northern blot 3   17
cDNA source data(298)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(307) Genomic(3) cDNA(302) Primer pair(2)
Microarray probesets(2)
Pathways
fatty acid β-oxidation I
Other database
links
EC 1.3.99.3
Ensembl Gene Model ENSMUSG00000062908
DoTS DT.110897825, DT.55107439, DT.94226152
Consensus CDS Project CCDS17924.1
UniGene 10530
DFCI TC1572783, TC1608421
NIA Mouse Gene Index U024783, U064660
Entrez Gene 11364
VEGA Gene Model OTTMUSG00000031346
International Mouse Knockout Project Status Acadm
Protein
domains
InterPro ID Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR006090 Acyl-CoA oxidase/dehydrogenase, type 1
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR006092 Acyl-CoA dehydrogenase, N-terminal
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase
IPR013764 Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:14629 Kelly DP et al., "Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue." Proc Natl Acad Sci U S A 1987 Jun;84(12):4068-72
(Latest) J:155190 Herrema H et al., "Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice." Hepatology 2008 Jun;47(6):1894-904
All references(28)
Other
accession IDs 		MGD-MRK-1024, MGI:2139874
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory