References
Query Results -- Details
MGI Accession ID: MGI:65782
J Number: J:17753
Other Accession IDs:
Title: Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5 [see comments]
Authors: Chisaka O; Capecchi MR
Journal: Nature
Volume: 350
Issue: 6318
Date: 1991 Apr 11
Year: 1991
Pages: 473-9
Review Status: Peer Reviewed
Abstract:
Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary tissue and exhibit a wide range of throat abnormalities. In addition, they often feature defects of the heart and arteries as well as craniofacial abnormalities. These deficiencies are remarkably similar to the pathology of the human congenital disorder DiGeorge's syndrome.
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