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| Nomenclature |
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Symbol:
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Tg(tetO-APPSwInd)102Dbo
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Name:
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transgene insertion 102, David R Borchelt
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MGI ID: |
MGI:3708167 |
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Synonyms: |
tet-APPswe/ind (line 102), tet-APPswe/ind line 102 |
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Transgene:
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Tg(tetO-APPSwInd)102Dbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x C3H/HeJ)F1
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Transgene
description |
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Transgene
Type: |
Transgenic (random, expressed) |
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Mutation: |
Insertion |
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The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2. Line 102 was established. When mice are crossed with a line expressing a tTA transgene, these mice show the greatest doxycycline sensitivity for transgene suppression. (J:80782, J:109829) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| Genotype | Allelic Composition | Genetic Background |
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  tg1
Disease Model |
Tg(tetO-APPSwInd)102Dbo/0 |
involves: C3H/HeJ * C57BL/6J |
phenotype not analyzed 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| Genotype | Allelic Composition | Genetic Background |
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tg2
Disease Model |
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0 |
involves: C3H/HeJ * C57BL/6 * CBA |
nervous system 1Models involving transgenes or other mutation types may also appear in other sections of the table.
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Disease
models
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1Models involving transgenes or other mutation types may also appear in other sections of the table.
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| References |
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Original: |
J:109829
Jankowsky JL et al.,
"Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease."
PLoS Med 2005 Dec;2(12):e355
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All: |
2 reference(s)
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