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| Nomenclature |
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Symbol:
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Hprt1tm7Detl
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Name:
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hypoxanthine guanine phosphoribosyl transferase 1;
targeted mutation 7, Peter J Detloff
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MGI ID: |
MGI:2668522 |
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Synonyms: |
hprtNosignalQ38 |
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Gene:
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Hprt1
Location:
ChrX:50341314-50374836 bp, + strand
Genetic Position: ChrX,
17.0 cM, cytoband A6
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:84451
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: |
Targeted (knock-in) |
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Mutations: |
Insertion, Disruption caused by insertion of vector |
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Exon 3 was disrupted by the insertion of a cassette containing a myc tag, and 38 CAG repeats encoding 38 glutamine residues. Neither a nuclear localization signal (NLS) nor a nuclear export signal (NES) was included in the targeting construct. (J:84451) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:84451
Jackson WS et al.,
"Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context."
Hum Mol Genet 2003 Jul 1;12(13):1621-9
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All: |
1 reference(s)
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