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Adamts20 Gene Detail
 Symbol
Name
ID
Adamts20
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
MGI:2660628


Nomenclature History
Synonyms ADAMTS-20, bt
Genetic Map
Chromosome 15
44.4 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 34)

Sequence Map
Chr15:94100594-94295849 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Adamts20 ± 2 cM)
TreeFam: TF331949
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000025504 VEGA Gene Model | MGI Sequence Detail 195256 C57BL/6J ± Kb
transcript NM_001164785 RefSeq | MGI Sequence Detail 6988 C57BL/6
polypeptide P59511 UniProt | EBI | MGI Sequence Detail 1906 Not Applicable
For the selected sequences
All sequences(29)
Alleles
and
phenotypes
All alleles(17) : Targeted, other(1) Spontaneous(11) Chemically induced(5)
Homozygous mutants have a white belt across the back in the midtrunk region and a white belly patch that coalesces to form a white belt.
Phenotype Images (1)  
Polymorphisms SNPs within 2kb(1229 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(25)
Process extracellular matrix organization, integrin-mediated signaling pathway...
Component extracellular matrix, extracellular region...
Function endopeptidase activity, hydrolase activity...
External Resources: MouseFunc
Expression Literature Summary: (3 records)
Data Summary: Assays (5)    Results (31)    Tissues (25)    Images (15)
Theiler Stages: 10,15,17,18,19,20,21,22,23,25,26,28
  Assay Type Assays   Results
      RNA in situ 2   22
      Northern blot 3   9
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000022449
DoTS DT.101370808, DT.101370809, DT.40137192, DT.97405500
UniGene 214132
DFCI TC1587713, TC1674195, TC1699013
NIA Mouse Gene Index U036573
Entrez Gene 223838
VEGA Gene Model OTTMUSG00000025504
International Mouse Knockout Project Status Adamts20
Protein
domains
InterPro ID Description
IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR010294 ADAM-TS Spacer 1
IPR012314 Peptidase M12B, GON-ADAMTSs
IPR013273 Peptidase M12B, ADAM-TS
IPR018358 Disintegrin, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:283 Murray JM et al., "Belted, a new sixth chromosome mutation in the mouse" J Hered 1945;36():266-8
(Latest) J:136961 Zhang Y et al., "Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate." Development 2008 Jun;135(12):2161-72
All references(47)
Other
accession IDs
MGD-MRK-1678, MGI:88212

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory