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Cpt1c Gene Detail
 Symbol
Name
ID
Cpt1c
carnitine palmitoyltransferase 1c
MGI:2446526


Nomenclature History
Synonyms 9630004I06Rik, CPT I-C
Genetic Map
Chromosome 7
cytoband B2
 
Mapping data( 2)
Sequence Map
Chr7:52214743-52230104 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF313836
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000007783 Ensembl Gene Model | MGI Sequence Detail 15362 C57BL/6J ± Kb
transcript NM_153679 RefSeq | MGI Sequence Detail 2716 C57BL/6
polypeptide Q8BGD5 UniProt | EBI | MGI Sequence Detail 798 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes
All alleles(20) : Targeted, knock-out(2) Gene trapped(18)
Targeted mutations in this gene result in reduced body weight, increases in circulating fatty acid levels and mild insulin resistance.
Polymorphisms SNPs within 2kb(132 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process fatty acid metabolic process, lipid metabolic process...
Component integral to membrane, membrane...
Function acyltransferase activity, carnitine O-palmitoyltransferase activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Assays (1)    Results (94)    Tissues (94)    Images (10)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   94
cDNA source data(32)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(2)
Microarray probesets(1)
Other database
links
EC 2.3.1.21
Ensembl Gene Model ENSMUSG00000007783
DoTS DT.101366701, DT.101724922, DT.111001483, DT.97351320
Consensus CDS Project CCDS21221.1
UniGene 231465
DFCI TC1579741, TC1592214, TC1618217
NIA Mouse Gene Index U123195
Entrez Gene 78070
International Mouse Knockout Project Status Cpt1c
Protein
domains
InterPro ID Description
IPR000542 Acyltransferase ChoActase/COT/CPT
Graphical View of Protein Domain Structure
References
(Earliest) J:79496 Price N et al., "A novel brain-expressed protein related to carnitine palmitoyltransferase I." Genomics 2002 Oct;80(4):433-42
(Latest) J:148205 Gao XF et al., "Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake." Diabetologia 2009 May;52(5):912-20
All references(12)
Other
accession IDs
MGI:2442291

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory