References
Query Results -- Details
MGI Accession ID: MGI:2429377
J Number: J:80000
Other Accession IDs:
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
Authors: The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team
Journal: Nature
Volume: 420
Issue:
Date: 2002
Year: 2002
Pages: 563-573
Review Status: Peer Reviewed
Abstract:
Only a small proportion of the mouse genome is transcribed into mature messenger
RNA transcripts. There is an international collaborative effort to identify all
full-length mRNA transcripts from the mouse, and to ensure that each is represented
in a physical collection of clones. Here we report the manual annotation of 60,770
full-length mouse complementary DNA sequences. These are clustered into 33,409
'transcriptional units', contributing 90.1% of a newly established mouse
transcriptome database. Of these transcriptional units, 4,258 are new protein-coding
and 11,665 are new non-coding messages, indicating that non-coding RNA is a major
component of the transcriptome. 41% of all transcriptional units showed evidence of
alternative splicing. In protein-coding transcripts, 79% of splice variations altered
the protein product. Whole-transcriptome analyses resulted in the identification of
2,431 sense-antisense pairs. The present work, completely supported by physical
clones, provides the most comprehensive survey of a mammalian transcriptome so
far, and is a valuable resource for functional genomics.
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