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Sgk3 Gene Detail
 Symbol
Name
ID
Sgk3
serum/glucocorticoid regulated kinase 3
MGI:2182368


Nomenclature History
Synonyms 2510015P22Rik, A330005P07Rik, Cisk, cytokine-independent survival kinase, fy, Sgkl
Genetic Map
Chromosome 1
7.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 53)

Sequence Map
Chr1:9788234-9889929 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Sgk3 ± 2 cM)
Protein SuperFamily: RAC serine/threonine-protein kinase
TreeFam: TF320906
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000025915 Ensembl Gene Model | MGI Sequence Detail 101696 C57BL/6J ± Kb
transcript NM_133220 RefSeq | MGI Sequence Detail 5517 C57BL/6
polypeptide Q9ERE3 UniProt | EBI | MGI Sequence Detail 496 Not Applicable
For the selected sequences
All sequences(58)
Alleles
and
phenotypes
All alleles(16) : Targeted, knock-out(2) Gene trapped(7) Spontaneous(7)
Mutations in this gene result in hair and vibrissae abnormalities due to defects in hair follicle morphogenesis.
Phenotype Images (3)  
Polymorphisms SNPs within 2kb(387 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(15)
Process anti-apoptosis, cell communication...
Component cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle...
Function ATP binding, kinase activity...
External Resources: MouseFunc
Expression cDNA source data(58)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(61) cDNA(61)
Microarray probesets(4)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000025915
DoTS DT.101227085, DT.101351121, DT.101404206, DT.103582864, DT.110921769, DT.50315334, DT.94168454, DT.97350566, DT.99844354, DT.99856821
UniGene 336410
PDB 1XTE, 1XTN
DFCI TC1576718, TC1594961, TC1596485, TC1610744, TC1624262, TC1664427
NIA Mouse Gene Index U000025
Entrez Gene 170755
International Mouse Knockout Project Status Sgk3
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR001683 Phox-like
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR017892 Protein kinase, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:90 DICKIE MM et al., "Fuzzy mice." J Hered 1950 Jul;41(7):193-6
(Latest) J:125551 Campagna DR et al., "Mutations in the Serum/Glucocorticoid regulated kinase 3 (Sgk3) are responsible for the mouse Fuzzy (fz) hair phenotype" J Invest Dermatol 2008 Mar;128(3):730-2
All references(49)
Other
accession IDs
MGD-MRK-9908, MGD-MRK-9910, MGI:1919672, MGI:2443375, MGI:95603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
Web browser compatibility
The Jackson Laboratory