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Gsk3a Gene Detail
 Symbol
Name
ID
Gsk3a
glycogen synthase kinase 3 alpha
MGI:2152453


Nomenclature History
Synonyms 2700086H06Rik
Genetic Map
Chromosome 7
Syntenic
 
Mapping data( 2)
Sequence Map
Chr7:26013277-26022870 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF101104
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021123 VEGA Gene Model | MGI Sequence Detail 9594 C57BL/6J ± Kb
transcript NM_001031667 RefSeq | MGI Sequence Detail 2276 C57BL/6
polypeptide Q2NL51 UniProt | EBI | MGI Sequence Detail 490 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(2)
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin sensitivity, decreased fat mass and increased lean mass.
Polymorphisms SNPs within 2kb(31 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process protein amino acid phosphorylation
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (8 records)
Data Summary: Assays (5)    Results (28)    Tissues (9)    Images (7)
Theiler Stages: 1,2,3,5,28
  Assay Type Assays   Results
      Western blot 3   24
      Immunohistochemistry 2   4
cDNA source data(4)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(6) cDNA(4) Other(2) Antibodies(4)
Microarray probesets(1)
Other database
links
EC 2.7.11.26
Ensembl Gene Model ENSMUSG00000057177
Consensus CDS Project CCDS20976.1
Entrez Gene 606496
VEGA Gene Model OTTMUSG00000021123
International Mouse Knockout Project Status Gsk3a
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:154623 Kim WY et al., "GSK-3 is a master regulator of neural progenitor homeostasis." Nat Neurosci 2009 Nov;12(11):1390-7
All references(30)
Other
accession IDs
MGI:1924078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory