Symbol
Name
ID
|
|
|
Synonyms
|
Cbl-b
|
|
Genetic Map
|
|
Chromosome 16
|
Syntenic
|
|
|
|
Mapping data(
2)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(49)
|
Alleles
and
phenotypes
|
All alleles(11) :
Targeted, knock-out(2)
Targeted, other(1)
Gene trapped(8)
| Homozygotes for targeted null mutations exhibit elevated IL2 production by T cells, develop spontaneous autoimmunity, and are highly susceptible to experimental autoimmune encephalomyelitis. |
|
|
Polymorphisms
|
SNPs within 2kb(1100 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
cDNA source data(43)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(43)
cDNA(43)
Microarray probesets(1)
|
Other database
links
|
| Ensembl Gene Model |
ENSMUSG00000022637 |
| DoTS |
DT.101199577, DT.101389036, DT.110726186, DT.40138210, DT.40174898, DT.91288298, DT.91564962, DT.94151764, DT.94191322 |
| Consensus CDS Project |
CCDS37355.1 |
| UniGene |
328206 |
| DFCI |
TC1603117, TC1615748, TC1617716, TC1624932, TC1653735, TC1665158, TC1707464 |
| NIA Mouse Gene Index |
U017207, U055435, U055437, U055441 |
| Entrez Gene |
208650 |
| International Mouse Knockout Project Status |
Cblb |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000449 |
Ubiquitin-associated/translation elongation factor EF1B, N-terminal |
| IPR000980 |
SH2 motif |
| IPR001841 |
Zinc finger, RING-type |
| IPR003153 |
Adaptor protein Cbl, N-terminal helical |
| IPR011992 |
EF-hand-like domain |
| IPR014741 |
Adaptor protein Cbl, EF hand-like |
| IPR014742 |
Adaptor protein Cbl, SH2-like |
| IPR015940 |
Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote |
| IPR017907 |
Zinc finger, RING-type, conserved site |
| IPR018957 |
Zinc finger, C3HC4 RING-type |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:76896
Bachmaier K et al.,
"Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b."
Nature 2000 Jan 13;403(6766):211-6
(Latest)
J:153814
St Rose MC et al.,
"The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells."
J Immunol 2009 Oct 15;183(8):4975-83
|
All references(47)
|
Other
accession IDs
|
MGI:2146506
|
Analysis Tools
MGI BioMart