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Pcsk9 Gene Detail
 Symbol
Name
ID
Pcsk9
proprotein convertase subtilisin/kexin type 9
MGI:2140260


Nomenclature History
Synonyms Narc1
Genetic Map
Chromosome 4
Syntenic
 
Mapping data( 1)
Sequence Map
Chr4:106114934-106136934 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; rat    (Mammalian Orthology)
Protein SuperFamily: proprotein convertase, subtilisin/kexin type 9
TreeFam: TF106271
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000008197 VEGA Gene Model | MGI Sequence Detail 22001 C57BL/6J ± Kb
transcript NM_153565 RefSeq | MGI Sequence Detail 3512 C57BL/6
polypeptide Q80W65 UniProt | EBI | MGI Sequence Detail 694 Not Applicable
For the selected sequences
All sequences(19)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Homozygous null mice exhibit increased clearance of circulating cholesterol and decreased plasma cholesterol levels.
Polymorphisms SNPs within 2kb(248 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(27)
Process cellular response to insulin stimulus, cellular response to starvation...
Component extracellular region, extracellular space...
Function calcium ion binding, hydrolase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (19)    Tissues (15)    Images (6)
Theiler Stages: 14,20,23,25,28
  Assay Type Assays   Results
      RNA in situ 1   19
cDNA source data(16)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000044254
DoTS DT.99853987
UniGene 133268
DFCI TC1583137
NIA Mouse Gene Index U025326
Entrez Gene 100102
VEGA Gene Model OTTMUSG00000008197
International Mouse Knockout Project Status Pcsk9
Protein
domains
InterPro ID Description
IPR000209 Peptidase S8/S53, subtilisin/kexin/sedolisin
IPR010259 Proteinase inhibitor I9, subtilisin propeptide
IPR015500 Peptidase S8, subtilisin-related
Graphical View of Protein Domain Structure
References
(Earliest) J:81825 Seidah NG et al., "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation." Proc Natl Acad Sci U S A 2003 Feb 4;100(3):928-33
(Latest) J:152865 Georgas K et al., "Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment." Dev Biol 2009 Aug 15;332(2):273-86
All references(16)
Other
accession IDs
MGI:2140355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory