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Hadhb Gene Detail
 Symbol
Name
ID
Hadhb
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
MGI:2136381

Nomenclature History
Synonyms 4930479F15Rik, Mtpb
Genetic Map
Chromosome 5
Syntenic
 
Mapping data( 1)
Sequence Map
Chr5:30481788-30511133 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: acetyl-CoA acetyltransferase
TreeFam: TF315243
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024744 VEGA Gene Model | MGI Sequence Detail 29346 C57BL/6J ± Kb
transcript NM_145558 RefSeq | MGI Sequence Detail 1963 FVB/N
polypeptide Q99JY0 UniProt | EBI | MGI Sequence Detail 475 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes 		All alleles(5) : Gene trapped(4) Chemically induced(1)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(115 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process fatty acid beta-oxidation, fatty acid metabolic process...
Component mitochondrial inner membrane, mitochondrion...
Function acetyl-CoA C-acyltransferase activity, acyltransferase activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Assays (2)    Results (11)    Tissues (4)    Images (2)
Theiler Stages: 26,28
  Assay Type Assays   Results
      Western blot 2   11
cDNA source data(12)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(12) cDNA(12) Antibodies(1)
Microarray probesets(3)
Pathways
fatty acid β-oxidation I
β-ketoadipate degradation
fatty acid β-oxidation II (core pathway)
phenylacetate degradation I
Other database
links
EC 2.3.1.16
Ensembl Gene Model ENSMUSG00000059447
DoTS DT.101403284, DT.101739617, DT.102535103, DT.110694607, DT.40141306, DT.536652, DT.94280398
Consensus CDS Project CCDS39045.1
DFCI TC1571973
Entrez Gene 231086
VEGA Gene Model OTTMUSG00000024744
International Mouse Knockout Project Status Hadhb
Protein
domains
InterPro ID Description
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020610 Thiolase, active site
IPR020613 Thiolase, conserved site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020616 Thiolase, N-terminal
IPR020617 Thiolase, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(11)
Other
accession IDs 		MGI:1922043
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory