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Crb1 Gene Detail
 Symbol
Name
ID
Crb1
crumbs homolog 1 (Drosophila)
MGI:2136343


Nomenclature History
Synonyms 7530426H14Rik, A930008G09Rik
Genetic Map
Chromosome 1
73.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr1:141093633-141273677 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Crb1 ± 2 cM)
TreeFam: TF316224
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000033974 VEGA Gene Model | MGI Sequence Detail 180045 C57BL/6J ± Kb
transcript NM_133239 RefSeq | MGI Sequence Detail 4702 -
polypeptide Q8VHS2 UniProt | EBI | MGI Sequence Detail 1405 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Targeted, other(1) Spontaneous(1)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (2)  
Polymorphisms SNPs within 2kb(1026 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(8)
Process eye photoreceptor cell development, membrane organization...
Component integral to membrane, membrane...
Function calcium ion binding
External Resources: MouseFunc
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (100)    Tissues (96)    Images (18)
Theiler Stages: 11,13,22,28
  Assay Type Assays   Results
      RNA in situ 2   94
      Immunohistochemistry 1   6
cDNA source data(29)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(31) cDNA(29) Primer pair(1) Other(1) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000063681
DoTS DT.101370696, DT.102555912, DT.91326317, DT.91336282, DT.91345779
UniGene 95700
DFCI TC1584581, TC1587022, TC1594547, TC1614074
NIA Mouse Gene Index U021836
Entrez Gene 170788
VEGA Gene Model OTTMUSG00000033974
International Mouse Knockout Project Status Crb1
Protein
domains
InterPro ID Description
IPR000152 EGF-type aspartate/asparagine hydroxylation site
IPR000742 EGF-like, type 3
IPR001438 EGF-like, type 2
IPR001791 Laminin G
IPR001881 EGF-like calcium-binding
IPR006209 EGF
IPR006210 EGF-like
IPR008985 Concanavalin A-like lectin/glucanase
IPR012680 Laminin G, subdomain 2
IPR013032 EGF-like region, conserved site
IPR013320 Concanavalin A-like lectin/glucanase, subgroup
IPR018097 EGF-like calcium-binding, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:73806 den Hollander AI et al., "Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain." Mech Dev 2002 Jan;110(1-2):203-7
(Latest) J:135160 Gosens I et al., "Composition and function of the Crumbs protein complex in the mammalian retina." Exp Eye Res 2008 May;86(5):713-26
All references(15)
Other
accession IDs
MGI:2442131, MGI:2443401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory