Symbol
Name
ID
|
Hadha
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
MGI:2135593
|
Nomenclature History
|
|
|
Synonyms
|
Mtpa
|
|
Genetic Map
|
|
Chromosome 5
|
Syntenic
|
|
|
|
Mapping data(
1)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(50)
|
Alleles
and
phenotypes
|
All alleles(5) :
Targeted, knock-out(1)
Gene trapped(4)
| Mice homozygous for disruptions in this gene die within 36 hours with hypoglycemia and liver steatosis. Liver steatosis and insulin resistance develop in heterozygotes with age. |
|
|
Polymorphisms
|
SNPs within 2kb(208 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (2 records)
Data Summary:
Assays (3)
Results (106)
Tissues (96)
Images (21)
Theiler Stages: 22,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
6 |
| |
RNA in situ |
1 |
|
94 |
| |
Northern blot |
1 |
|
6 |
cDNA source data(212)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(213)
cDNA(212)
Primer pair(1)
Antibodies(1)
Microarray probesets(2)
|
|
Pathways
|
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR001753 |
Crotonase, core |
| IPR006108 |
3-hydroxyacyl-CoA dehydrogenase, C-terminal |
| IPR006176 |
3-hydroxyacyl-CoA dehydrogenase, NAD binding |
| IPR006180 |
3-hydroxyacyl-CoA dehydrogenase, conserved site |
| IPR008927 |
6-phosphogluconate dehydrogenase, C-terminal-like |
| IPR012803 |
Fatty acid oxidation complex, alpha subunit, mitochondrial |
| IPR013328 |
Dehydrogenase, multihelical |
| IPR016040 |
NAD(P)-binding domain |
| IPR018376 |
Enoyl-CoA hydratase/isomerase, conserved site |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:60984
Ko MS et al.,
"Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development."
Development 2000 Apr;127(8):1737-49
(Latest)
J:151002
Pagliarini DJ et al.,
"A mitochondrial protein compendium elucidates complex I disease biology."
Cell 2008 Jul 11;134(1):112-23
|
All references(10)
|
Other
accession IDs
|
MGI:2141283
|
Analysis Tools
MGI BioMart