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Kars Gene Detail
 Symbol
Name
ID
Kars
lysyl-tRNA synthetase
MGI:1934754


Nomenclature History
Synonyms D8Ertd698e, D8Wsu108e, LysRS, mKIAA0070
Genetic Map
Chromosome 8
55.0 cM, cytoband D3
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr8:114517343-114535168 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Kars ± 2 cM)
Protein SuperFamily: lysine-tRNA ligase
TreeFam: TF300365
Sequences
Representative Sequences Length Strain/Species Flank
genomic 85305 NCBI Gene Model | MGI Sequence Detail 17826 C57BL/6J ± Kb
transcript NM_001130868 RefSeq | MGI Sequence Detail 2173 -
polypeptide Q99MN1 UniProt | EBI | MGI Sequence Detail 595 Not Applicable
For the selected sequences
All sequences(53)
Alleles
and
phenotypes
All alleles(16) : Gene trapped(16)
Polymorphisms SNPs within 2kb(128 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(18)
Process lysyl-tRNA aminoacylation, translation...
Component cytoplasm, mitochondrion...
Function aminoacyl-tRNA ligase activity, ATP binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (1 records)
Data Summary: Assays (1)    Results (6)    Tissues (2)
Theiler Stages: 11
  Assay Type Assays   Results
      RT-PCR 1   6
cDNA source data(10)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(2)
Pathways
tRNA charging pathway
Other database
links
EC 6.1.1.6
Ensembl Gene Model ENSMUSG00000031948
DoTS DT.101385419, DT.101385426, DT.101385429, DT.110876008, DT.496447, DT.55137285, DT.97362532
DFCI TC1571983, TC1729826
Entrez Gene 85305
International Mouse Knockout Project Status Kars
Protein
domains
InterPro ID Description
IPR002313 Lysyl-tRNA synthetase, class II
IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
IPR004365 Nucleic acid binding, OB-fold, tRNA/helicase-type
IPR006195 Aminoacyl-tRNA synthetase, class II, conserved region
IPR012340 Nucleic acid-binding, OB-fold
IPR016027 Nucleic acid-binding, OB-fold-like
IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like
Graphical View of Protein Domain Structure
References
(Earliest) J:50869 Ko MSH et al., "Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome." Hum Mol Genet 1998 Nov;7(12):1967-78
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(11)
Other
accession IDs
MGD-MRK-34116, MGI:106422, MGI:1277111, MGI:2142434, MGI:2142665, MGI:2142669, MGI:2142671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory