Symbol
Name
ID
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Synonyms
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2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, Frap1, RAFT1, RAPT1
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Genetic Map
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Sequence Map
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Mammalian homology
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Sequences
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All sequences(30)
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Alleles and phenotypes
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All alleles(17) :
Targeted, knock-out(2)
Targeted, other(2)
Gene trapped(12)
Chemically induced(1)
| Mice homozygous for a null allele exhibit embryonic lethality by E12.5 due to abnormal embryogenesis. Mice homozygous for an ENU mutation exhibit embryonic lethality by E12.5 with abnormal embryogenesis and brain development. Mice homozygous for a gene trap allele exhibit abnormal embryogenesis. |
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Polymorphisms
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SNPs within 2kb(774 from dbSNP Build 128)
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Gene Ontology (GO) classifications
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Expression
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Literature Summary: (12 records)
cDNA source data(144)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
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Molecular reagents
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All nucleic(148)
Genomic(2)
cDNA(145)
Primer pair(1)
Microarray probesets(3)
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Other database links
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Protein domains
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| InterPro ID |
Description |
| IPR000403 |
Phosphatidylinositol 3-/4-kinase, catalytic |
| IPR003151 |
PIK-related kinase, FAT |
| IPR003152 |
PIK-related kinase, FATC |
| IPR009076 |
FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding |
| IPR011009 |
Protein kinase-like domain |
| IPR011989 |
Armadillo-like helical |
| IPR014009 |
PIK-related kinase |
| IPR016024 |
Armadillo-type fold |
| IPR018936 |
Phosphatidylinositol 3/4-kinase, conserved site |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:53291
Hentges K et al.,
"The flat-top gene is required for the expansion and regionalization of the telencephalic primordium."
Development 1999 Apr;126(8):1601-9
(Latest)
J:154054
Lange A et al.,
"Integrin-linked kinase is an adaptor with essential functions during mouse development."
Nature 2009 Oct 15;461(7266):1002-6
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All references(68)
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Other accession IDs
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MGI:1332655, MGI:1919780, MGI:2140250
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