Symbol
Name
ID
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Synonyms
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2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, Frap1, RAFT1, RAPT1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(30)
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Alleles
and
phenotypes
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All alleles(15) :
Targeted, knock-out(2)
Targeted, other(2)
Gene trapped(10)
Chemically induced(1)
| Mice homozygous for a null allele exhibit embryonic lethality by E12.5 due to abnormal embryogenesis. Mice homozygous for an ENU mutation exhibit embryonic lethality by E12.5 with abnormal embryogenesis and brain development. Mice homozygous for a gene trap allele exhibit abnormal embryogenesis. |
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Polymorphisms
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SNPs within 2kb(774 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (11 records)
cDNA source data(143)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(146)
Genomic(2)
cDNA(144)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000403 |
Phosphatidylinositol 3-/4-kinase, catalytic |
| IPR003151 |
PIK-related kinase, FAT |
| IPR003152 |
PIK-related kinase, FATC |
| IPR009076 |
FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding |
| IPR011009 |
Protein kinase-like domain |
| IPR011989 |
Armadillo-like helical |
| IPR014009 |
PIK-related kinase |
| IPR016024 |
Armadillo-type fold |
| IPR018936 |
Phosphatidylinositol 3- and 4-kinase, conserved site |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:53291
Hentges K et al.,
"The flat-top gene is required for the expansion and regionalization of the telencephalic primordium."
Development 1999 Apr;126(8):1601-9
(Latest)
J:153715
Jin N et al.,
"Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis."
Development 2009 Oct;136(19):3347-56
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All references(64)
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Other
accession IDs
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MGI:1332655, MGI:1919780, MGI:2140250
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