About   Help   FAQ
Sv2b Gene Detail
 Symbol
Name
ID
Sv2b
synaptic vesicle glycoprotein 2 b
MGI:1927338


Nomenclature History
Synonyms A830038F04Rik, mKIAA0735
Genetic Map
Chromosome 7
cytoband D1
 
Mapping data( 3)
Sequence Map
Chr7:82259780-82351581 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: synaptic vesicle protein SV2
TreeFam: TF324824
Sequences
Representative Sequences Length Strain/Species Flank
genomic 64176 NCBI Gene Model | MGI Sequence Detail 91802 C57BL/6J ± Kb
transcript NM_153579 RefSeq | MGI Sequence Detail 5548 C57BL/6
polypeptide Q8BG39 UniProt | EBI | MGI Sequence Detail 683 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(2)
Homozygotes for a targeted null mutation are phenotypically normal, and Sv2a/Sv2b double knockouts are no more affected than Sv2a single knockouts.
Polymorphisms SNPs within 2kb(288 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process neurotransmitter transport, protein transport...
Component cell junction, cytoplasmic vesicle...
Function protein binding, receptor activity...
External Resources: FuncBase
Expression Literature Summary: (18 records)
Data Summary: Assays (3)    Results (113)    Tissues (106)    Images (23)
Theiler Stages: 21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 1   7
      RNA in situ 2   106
cDNA source data(35)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(36) cDNA(36) Antibodies(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000053025
DoTS DT.101736645, DT.101736646, DT.55154341, DT.55281227, DT.94166889, DT.99852217
Consensus CDS Project CCDS21368.1
UniGene 273082
DFCI TC1580517, TC1603349, TC1633352
NIA Mouse Gene Index U080092
Entrez Gene 64176
International Mouse Knockout Project Status Sv2b
Protein
domains
InterPro ID Description
IPR005828 General substrate transporter
IPR005829 Sugar transporter, conserved site
IPR005988 Synaptic vesicle protein SV2
IPR011701 Major facilitator superfamily MFS-1
IPR016196 Major facilitator superfamily, general substrate transporter
Graphical View of Protein Domain Structure
References
(Earliest) J:33098 Gautam M et al., "Defective neuromuscular synaptogenesis in agrin-deficient mutant mice." Cell 1996 May 17;85(4):525-35
(Latest) J:148272 Morgans CW et al., "Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina." PLoS ONE 2009;4(4):e5230
All references(28)
Other
accession IDs
MGI:2142055, MGI:2443605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory