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Kcnq4 Gene Detail
 Symbol
Name
ID
Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
MGI:1926803


Nomenclature History
Genetic Map
Chromosome 4
Syntenic
 
Mapping data( 1)
Sequence Map
Chr4:120368743-120421217 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: potassium voltage-gated channel, subfamily KQT
TreeFam: TF315186
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000008856 VEGA Gene Model | MGI Sequence Detail 52475 C57BL/6J ± Kb
transcript NM_001081142 RefSeq | MGI Sequence Detail 2512 -
polypeptide Q9JK97 UniProt | EBI | MGI Sequence Detail 696 Not Applicable
For the selected sequences
All sequences(16)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Targeted, other(1)
Polymorphisms SNPs within 2kb(312 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(18)
Process inner ear morphogenesis, ion transport...
Component integral to membrane, membrane...
Function ion channel activity, potassium channel activity...
External Resources: MouseFunc
Expression Literature Summary: (4 records)
Data Summary: Assays (3)    Results (12)    Tissues (7)
Theiler Stages: 23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 3   12
cDNA source data(9)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(9) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000028631
DoTS DT.101215805, DT.91391425
UniGene 249977
DFCI TC1601535, TC1609558
NIA Mouse Gene Index U025479
Entrez Gene 60613
VEGA Gene Model OTTMUSG00000008856
International Mouse Knockout Project Status Kcnq4
Protein
domains
InterPro ID Description
IPR003091 Voltage-dependent potassium channel
IPR003937 Potassium channel, voltage dependent, KCNQ
IPR005821 Ion transport
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
IPR015573 Potassium channel, voltage dependent, KCNQ4
Graphical View of Protein Domain Structure
References
(Earliest) J:65445 Beisel KW et al., "Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2(1)" Brain Res Mol Brain Res 2000 Oct 20;82(1-2):137-49
(Latest) J:132603 Saul SM et al., "Math5 expression and function in the central auditory system." Mol Cell Neurosci 2008 Jan;37(1):153-69
All references(9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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