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Pak7 Gene Detail
 Symbol
Name
ID
Pak7
p21 protein (Cdc42/Rac)-activated kinase 7
MGI:1920334


Nomenclature History
Synonyms 2900083L08Rik, Pak5
Genetic Map
Chromosome 2
Syntenic
 
Mapping data( 1)
Sequence Map
Chr2:135906840-136213703 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF105352
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000015988 VEGA Gene Model | MGI Sequence Detail 306864 C57BL/6J ± Kb
transcript NM_172858 RefSeq | MGI Sequence Detail 4773 C57BL/6
polypeptide Q8C015 UniProt | EBI | MGI Sequence Detail 719 Not Applicable
For the selected sequences
All sequences(29)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(1) Gene trapped(1)
Homozygous null mice exhibit impaired active avoidance learning but are otherwise normal.
Polymorphisms SNPs within 2kb(1076 from dbSNP Build 128)   SNPs within 2kb including multiple locations(1080)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process anti-apoptosis, protein amino acid phosphorylation...
Component mitochondrion
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (3)    Results (17)    Tissues (10)
Theiler Stages: 28
  Assay Type Assays   Results
      Western blot 2   11
      RNA in situ 1   6
cDNA source data(25)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(26) cDNA(25) Other(1) Antibodies(1)
Microarray probesets(1)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000039913, ENSMUSG00000080197
DoTS DT.101362897, DT.110704818, DT.97334195, DT.97386715
Consensus CDS Project CCDS16790.1
UniGene 131572
DFCI TC1581121, TC1592110, TC1609376
NIA Mouse Gene Index U023408
Entrez Gene 241656
VEGA Gene Model OTTMUSG00000015988
International Mouse Knockout Project Status Pak7
Protein
domains
InterPro ID Description
IPR000095 PAK-box/P21-Rho-binding
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR011009 Protein kinase-like domain
IPR015750 Serine/threonine-protein kinase, Pak-related
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:145866 Gobert RP et al., "Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits." Mol Cell Biol 2009 Mar;29(6):1538-53
All references(9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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