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Vav3 Gene Detail
 Symbol
Name
ID
Vav3
vav 3 oncogene
MGI:1888518

Nomenclature History
Synonyms A530094I06Rik
Genetic Map
Chromosome 3
cytoband G1
 
Mapping data( 4)
Sequence Map
Chr3:109143571-109488616 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: vav transforming protein
TreeFam: TF316171
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000007363 VEGA Gene Model | MGI Sequence Detail 345046 C57BL/6J ± Kb
transcript NM_020505 RefSeq | MGI Sequence Detail 5023 C57BL/6
polypeptide Q9R0C8 UniProt | EBI | MGI Sequence Detail 847 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(2) Gene trapped(2)
Homozygous mutation of this gene results in tachycardia, systemic arterial hypertension, cardiovascular remodeling, hyperactivity of sympathetic neurons and thus high catecholamine levels, and increased levels of kidney-related hormones.
Polymorphisms SNPs within 2kb(1753 from dbSNP Build 128)   SNPs within 2kb including multiple locations(1767)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process angiogenesis, cell migration...
Component cytoplasm, intracellular...
Function epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity...
External Resources: FuncBase
Expression cDNA source data(34)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(34) cDNA(34)
Microarray probesets(4)
Other database
links
NIA Mouse Gene Index U003749
VEGA Gene Model OTTMUSG00000007363
Entrez Gene 57257
DoTS DT.101162917, DT.40182591, DT.87059674, DT.97358422
DFCI TC1581127, TC1590374, TC1611897
Ensembl Gene Model ENSMUSG00000033721
Consensus CDS Project CCDS17773.1
UniGene 282257
International Mouse Knockout Project Status Vav3
Protein
domains
InterPro ID Description
IPR000219 Dbl homology (DH) domain
IPR000980 SH2 motif
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001452 Src homology-3 domain
IPR001715 Calponin-like actin-binding
IPR001849 Pleckstrin homology
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR003096 SM22/calponin
IPR011511 Variant SH3
IPR011993 Pleckstrin homology-type
IPR013315 Spectrin alpha chain, SH3 domain
IPR016146 Calponin-homology
IPR020473 Src homology-3, region
Graphical View of Protein Domain Structure
References
(Earliest) J:63932 Moores SL et al., "Vav family proteins couple to diverse cell surface receptors." Mol Cell Biol 2000 Sep;20(17):6364-73
(Latest) J:155962 Ruiz S et al., "The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis." PLoS One 2009;4(12):e8229
All references(32)
Other
accession IDs 		MGI:2139612, MGI:2444834
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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