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| Nomenclature |
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Symbol:
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Sncatm1Rosl
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Name:
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synuclein, alpha;
targeted mutation 1, Arnon Rosenthal
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MGI ID: |
MGI:1888382 |
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Synonyms: |
alpha-Syn-, alpha-Synko |
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Gene:
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Snca
Location:
Chr6:60681573-60778833 bp, - strand
Genetic Position: Chr6,
29.0 cM
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Mutation
origin |
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Germline Transmission:
| Earliest citation of germline transmission:
J:60151
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: |
Targeted (knock-out) |
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Mutations: |
Insertion, Intragenic deletion |
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A PGK-neo cassette was used to delete exons 1 and 2, encoding amino acids 1 through 41 as well as a 5' untranslated region. RT-PCR analysis of extracts from the brains of homozygous mutant mice, using probes for both the deleted 5' region as well the untargeted 3' region, showed an absence of transcript. Western blot analysis, immunohistochemical analysis, and in situ hybridization confirmed a lack of encoded protein in homozygous mutant mice. (J:60151) |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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| References |
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Original: |
J:60151
Abeliovich A et al.,
"Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system."
Neuron 2000 Jan;25(1):239-52
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All: |
15 reference(s)
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