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Nfat5 Gene Detail
 Symbol
Name
ID
Nfat5
nuclear factor of activated T-cells 5
MGI:1859333


Nomenclature History
Synonyms B130038B15Rik, mKIAA0827, nfatz, OREBP, TonEBP
Genetic Map
Chromosome 8
53.0 cM, cytoband D2
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr8:109817370-109903417 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Nfat5 ± 2 cM)
TreeFam: TF326480
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000033607 VEGA Gene Model | MGI Sequence Detail 86048 C57BL/6J ± Kb
transcript NM_133957 RefSeq | MGI Sequence Detail 13451 C57BL/6
polypeptide Q9WV30 UniProt | EBI | MGI Sequence Detail 1225 Not Applicable
For the selected sequences
All sequences(51)
Alleles
and
phenotypes
All alleles(10) : Targeted, knock-out(2) Gene trapped(8)
Homozygous null mutation of this gene results in progressive renal atrophy and disruption of osmoprotective gene expression.
Polymorphisms RFLP(1) SNPs within 2kb(133 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cytokine production, positive regulation of transcription from RNA polymerase II promoter...
Component cytoplasm, nucleus...
Function DNA binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (4)    Results (52)    Tissues (48)    Images (5)
Theiler Stages: 2,3,4,5,17,21,22,26,28
  Assay Type Assays   Results
      RT-PCR 2   20
      RNA in situ 2   32
cDNA source data(14)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(15) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000003847
Consensus CDS Project CCDS22648.1, CCDS40464.1
DFCI TC1575421, TC1590181, TC1594797, TC1605597, TC1618944, TC1629969
NIA Mouse Gene Index U042927, U370193
Entrez Gene 54446
VEGA Gene Model OTTMUSG00000033607
International Mouse Knockout Project Status Nfat5
Protein
domains
InterPro ID Description
IPR002909 Cell surface receptor IPT/TIG
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology
IPR013783 Immunoglobulin-like fold
IPR014756 Immunoglobulin E-set
IPR015646 Nuclear factor of activated T-cells 5
IPR018286 Nuclear factor of activated T cells (NFAT), subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:62063 Lopez-Rodriguez C et al., "NF-AT5: the NF-AT family of transcription factors expands in a new direction." Cold Spring Harb Symp Quant Biol 1999;64():517-26
(Latest) J:148695 Hao S et al., "Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells." Am J Physiol Renal Physiol 2009 Jun;296(6):F1494-503
All references(27)
Other
accession IDs
MGI:2142481, MGI:2442693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory