About   Help   FAQ
Tour our new Quick Search
Nxf1 Gene Detail
 Symbol
Name
ID
Nxf1
nuclear RNA export factor 1 homolog (S. cerevisiae)
MGI:1858330

Nomenclature History
Synonyms Mex67, Mvb1, TAP, Tip associated protein
Genetic Map
Chromosome 19
5.0 cM, cytoband A
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr19:8831593-8845399 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Nxf1 ± 2 cM)
TreeFam: TF314566
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000010097 Ensembl Gene Model | MGI Sequence Detail 13807 C57BL/6J ± Kb
transcript NM_016813 RefSeq | MGI Sequence Detail 2312 FVB/N
polypeptide Q99JX7 UniProt | EBI | MGI Sequence Detail 618 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes 		All alleles(14) : Gene trapped(12) QTL(2)
Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.
Polymorphisms SNPs within 2kb(32 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process mRNA transport, poly(A)+ mRNA export from nucleus...
Component cytoplasm, intracellular...
Function mRNA binding, nucleocytoplasmic transporter activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Assays (2)    Results (22)    Tissues (22)    Images (3)
Theiler Stages: 21,28
  Assay Type Assays   Results
      RT-PCR 1   2
      RNA in situ 1   20
cDNA source data(10)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000010097
DoTS DT.101238802, DT.110859963, DT.110860010, DT.531445, DT.535203, DT.55279583
Consensus CDS Project CCDS29543.1
DFCI TC1573188, TC1628360, TC1764242
Entrez Gene 53319
International Mouse Knockout Project Status Nxf1
Protein
domains
InterPro ID Description
IPR002075 Nuclear transport factor 2
IPR003603 U2A'/phosphoprotein 32 family A, C-terminal
IPR005637 TAP, C-terminal
IPR009060 UBA-like
IPR012677 Nucleotide-binding, alpha-beta plait
IPR015245 Tap, RNA-binding
IPR018222 Nuclear transport factor 2, Eukaryote
Graphical View of Protein Domain Structure
References
(Earliest) J:40754 Hamilton BA et al., "The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression." Neuron 1997 May;18(5):711-22
(Latest) J:149430 Concepcion D et al., "Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing." PLoS Genet 2009 May;5(5):e1000484
All references(14)
Other
accession IDs 		MGI:1194888
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory