Symbol
Name
ID
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Synonyms
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Cish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(20)
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Alleles
and
phenotypes
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All alleles(7) :
Targeted, knock-out(4)
Targeted, other(3)
| Homozygotes for targeted null mutations exhibit retarded growth, hyperresponsiveness to endogenous interferon gamma, hepatitis with fatty degeneration, lymphopenia due to excess apoptosis, monocytic organ infiltration, and lethality by 3 weeks of age. |
Phenotype Images (2)
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Polymorphisms
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SNPs within 2kb(64 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (3 records)
cDNA source data(53)
External Resources:
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(55)
Genomic(1)
cDNA(54)
Microarray probesets(2)
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Other database
links
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Protein
domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:30554
Schluter G et al.,
"Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene."
Mol Reprod Dev 1996 Jan;43(1):1-6
(Latest)
J:155447
Calabrese V et al.,
"SOCS1 links cytokine signaling to p53 and senescence."
Mol Cell 2009 Dec 11;36(5):754-67
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All references(96)
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Other
accession IDs
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MGI:1276585
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Analysis Tools
MGI BioMart
