Symbol
Name
ID
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Synonyms
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5830428L06Rik, p110gamma, PI(3)Kgamma, PI3Kgamma, PI3Kgamma
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Genetic Map
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Chromosome 12
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cytoband B
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Mapping data(
3)
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(51)
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Alleles
and
phenotypes
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All alleles(6) :
Targeted, knock-out(1)
Targeted, other(5)
| Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration. |
Phenotype Images (1)
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Polymorphisms
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SNPs within 2kb(175 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (1 records)
cDNA source data(10)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(12)
Genomic(1)
cDNA(11)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000341 |
Phosphoinositide 3-kinase, ras-binding |
| IPR000403 |
Phosphatidylinositol 3-/4-kinase, catalytic |
| IPR001263 |
Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR002420 |
Phosphoinositide 3-kinase, C2 |
| IPR008973 |
C2 calcium/lipid-binding domain, CaLB |
| IPR011009 |
Protein kinase-like domain |
| IPR015433 |
Phosphatidylinositol Kinase |
| IPR016024 |
Armadillo-type fold |
| IPR018936 |
Phosphatidylinositol 3- and 4-kinase, conserved site |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:68953
Klesse LJ et al.,
"p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons."
J Neurosci 1998 Dec 15;18(24):10420-8
(Latest)
J:152446
Thomas M et al.,
"Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation."
Immunology 2009 Mar;126(3):413-22
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All references(99)
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Other
accession IDs
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MGI:1923289
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