Symbol
Name
ID
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Synonyms
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D5Ertd287e, Shrm, Shrm3
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(39)
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Alleles
and
phenotypes
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All alleles(138) :
Gene trapped(138)
| Homozygous mutation of this locus results in failed neural tube closure leading to exencephaly, acrania, facial clefting, and spina bifida. Homozygotes develop to term but die either at birth or shortly thereafter. |
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Polymorphisms
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SNPs within 2kb(1616 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (3 records)
Data Summary:
Assays (3)
Results (62)
Tissues (31)
Images (1)
Theiler Stages: 11,12,13,15,17,18,20,22
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Assay Type |
Assays |
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Results |
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Western blot |
1 |
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2 |
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In situ reporter (knock in) |
1 |
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54 |
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RNA in situ |
1 |
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6 |
cDNA source data(72)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(74)
cDNA(73)
Primer pair(1)
Antibodies(1)
Microarray probesets(5)
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Other database
links
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Protein
domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:58691
Hildebrand JD et al.,
"Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice."
Cell 1999 Nov 24;99(5):485-97
(Latest)
J:135984
Nishimura T et al.,
"Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling."
Development 2008 Apr;135(8):1493-502
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All references(16)
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Other
accession IDs
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MGI:1098648, MGI:2141015
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