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Adh4 Gene Detail
 Symbol
Name
ID
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
MGI:1349472

Nomenclature History
Synonyms Adh2, mouse class II type ADH
Genetic Map
Chromosome 3
cytoband H2
 
Mapping data( 3)
Sequence Map
Chr3:138078430-138093856 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Protein SuperFamily: alcohol dehydrogenase
TreeFam: TF300429
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000030507 VEGA Gene Model | MGI Sequence Detail 15427 C57BL/6J ± Kb
transcript NM_011996 RefSeq | MGI Sequence Detail 1312 C57BL/6
polypeptide Q9QYY9 UniProt | EBI | MGI Sequence Detail 377 Not Applicable
For the selected sequences
All sequences(18)
Polymorphisms SNPs within 2kb(47 from dbSNP Build 128)   SNPs within 2kb including multiple locations(49)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process alcohol catabolic process, cellular aldehyde metabolic process...
Component cytoplasm
Function alcohol dehydrogenase (NAD) activity, alcohol dehydrogenase activity, zinc-dependent...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (2)    Results (98)    Tissues (98)    Images (1)
Theiler Stages: 9,11,13,15,22
  Assay Type Assays   Results
      RT-PCR 1   4
      RNA in situ 1   94
cDNA source data(6)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(9) Genomic(1) cDNA(6) Primer pair(2)
Microarray probesets(2)
Pathways
phenylalanine degradation III
oxidative ethanol degradation I
Other database
links
EC 1.1.1.1
Ensembl Gene Model ENSMUSG00000037797
DoTS DT.482717, DT.91335604
Consensus CDS Project CCDS38653.1
PDB 1E3E, 1E3I, 1E3L
DFCI TC1588898
NIA Mouse Gene Index U003911
Entrez Gene 26876
VEGA Gene Model OTTMUSG00000030507
International Mouse Knockout Project Status Adh4
Protein
domains
InterPro ID Description
IPR002085 Alcohol dehydrogenase superfamily, zinc-containing
IPR002328 Alcohol dehydrogenase, zinc-containing, conserved site
IPR011032 GroES-like
IPR013149 Alcohol dehydrogenase, zinc-binding
IPR013154 Alcohol dehydrogenase GroES-like
IPR016040 NAD(P)-binding domain
Graphical View of Protein Domain Structure
References
(Earliest) J:6249 Holmes RS, "Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3." Biochem Genet 1979 Jun;17(5-6):461-72
(Latest) J:121381 Hu P et al., "Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal." Biochim Biophys Acta 2007 Apr;1770(4):694-705
All references(12)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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