Symbol
Name
ID
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Synonyms
|
fkh-1, Fkh1, fkh1, FREAC3, frkhda, Mf1, Mf4
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(23)
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Alleles
and
phenotypes
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All alleles(4) :
Targeted, other(2)
Spontaneous(1)
Chemically induced(1)
| Homozygous mutants are neonatal lethal with congenital hydrocephalus, edema, abnormalities of the eye, skull, axial skeleton, kidney-ureter and cardiovascular systems. Heterozygotes have variable milder defects depending on genetic background. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
Phenotype Images (3)
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Polymorphisms
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All PCR and RFLP(2) :
PCR(1)
RFLP(1)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (44 records)
Data Summary:
Assays (18)
Results (171)
Tissues (124)
Images (39)
Theiler Stages: 10,11,12,13,14,15,17,18,19,20,21,22,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RNA in situ |
9 |
|
98 |
| |
Northern blot |
5 |
|
34 |
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RNase protection |
4 |
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39 |
cDNA source data(37)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(51)
Genomic(8)
cDNA(38)
Primer pair(2)
Other(3)
Microarray probesets(1)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR001766 |
Transcription factor, fork head |
| IPR011991 |
Winged helix repressor DNA-binding |
| IPR018122 |
Transcription factor, fork head, conserved site |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:75733
Gruneberg H,
"Congenital hydrocephalus in the mouse, a case of spurious pleiotropism"
J Genet 1943;45(1):1-21
(Latest)
J:152710
Aldinger KA et al.,
"FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation."
Nat Genet 2009 Sep;41(9):1037-42
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All references(79)
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Other
accession IDs
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MGD-MRK-16690, MGD-MRK-1966, MGD-MRK-24021, MGD-MRK-35060, MGD-MRK-9813, MGI:103155, MGI:88391, MGI:95544
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