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Mapk3 Gene Detail
 Symbol
Name
ID
Mapk3
mitogen-activated protein kinase 3
MGI:1346859

Nomenclature History
Synonyms Erk-1, Erk1, Esrk1, p44 MAP kinase, p44erk1, p44mapk, Prkm3
Genetic Map
Chromosome 7
61.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr7:133903115-133909333 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Mapk3 ± 2 cM)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF105097
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016478 VEGA Gene Model | MGI Sequence Detail 6219 C57BL/6J ± Kb
transcript NM_011952 RefSeq | MGI Sequence Detail 1772 FVB/N
polypeptide Q63844 UniProt | EBI | MGI Sequence Detail 380 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes 		All alleles(8) : Targeted, knock-out(3) Gene trapped(5)
Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation.
Polymorphisms RFLP(1) SNPs within 2kb(5 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(30)
Process cartilage development, cell cycle...
Component cytoplasm, nucleoplasm...
Function ATP binding, kinase activity...
External Resources: MouseFunc
Expression Literature Summary: (105 records)
Data Summary: Assays (21)    Results (265)    Tissues (165)    Images (39)
Theiler Stages: 2,3,4,5,17,18,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      Western blot 12   53
      RT-PCR 3   99
      RNA in situ 1   93
      Immunohistochemistry 5   20
cDNA source data(202)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(208) Genomic(2) cDNA(202) Primer pair(4) Antibodies(19)
Microarray probesets(2)
Other database
links
EC 2.7.11.24
Ensembl Gene Model ENSMUSG00000063065
DoTS DT.101408309, DT.535611
UniGene 8385
DFCI TC1574602
Entrez Gene 26417
VEGA Gene Model OTTMUSG00000016478
International Mouse Knockout Project Status Mapk3
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR003527 MAP kinase, conserved site
IPR008271 Serine/threonine-protein kinase, active site
IPR008349 ERK1/2 MAP kinase
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:31517 Crews CM et al., "Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine." Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8845-9
(Latest) J:153980 Matsushita T et al., "Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis." Mol Cell Biol 2009 Nov;29(21):5843-57
All references(210)
Other
accession IDs 		MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory