Symbol
Name
ID
|
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Genetic Map
|
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Chromosome 9
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Syntenic
|
|
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Mapping data(
2)
|
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(42)
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Alleles
and
phenotypes
|
All alleles(13) :
Targeted, knock-out(7)
Targeted, other(5)
Gene trapped(1)
| Some alleles with a targeted mutation exhibit small body size, postnatal lethality, hyperactivity, decreased anxiety, and abnormal APP processing by neurons, while others appear normal. |
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Polymorphisms
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SNPs within 2kb(309 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (3 records)
Data Summary:
Assays (3)
Results (15)
Tissues (4)
Images (3)
Theiler Stages: 22,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
4 |
| |
RT-PCR |
1 |
|
9 |
| |
Northern blot |
1 |
|
2 |
cDNA source data(18)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(23)
cDNA(21)
Primer pair(1)
Other(1)
Antibodies(1)
Microarray probesets(4)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR001461 |
Peptidase A1 |
| IPR001969 |
Peptidase aspartic, active site |
| IPR009007 |
Peptidase aspartic, catalytic |
| IPR009119 |
Peptidase A1, beta-site APP cleaving enzyme, BACE |
| IPR009120 |
Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1 |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:43334
Vassar R et al.,
"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE [see comments]"
Science 1999 Oct 22;286(5440):735-41
(Latest)
J:152969
Philipson O et al.,
"Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice."
FEBS Lett 2009 Sep 17;583(18):3021-6
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All references(45)
|
Other
accession IDs
|
MGI:2143381
|
