Symbol
Name
ID
|
|
|
Genetic Map
|
|
Chromosome X
|
cytoband A6
|
|
|
|
Mapping data(
1)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(16)
|
Alleles
and
phenotypes
|
All alleles(2) :
Targeted, knock-out(1)
Targeted, other(1)
| Mice homozygous for a knock-out allele exhibit increased susceptibility to DMBA- or DMBA plus TPA-induced skin tumors associated with decreased apoptosis in treated epidermis and keratinocytes. |
|
|
Polymorphisms
|
SNPs within 2kb(25 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (1 records)
cDNA source data(4)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(5)
Genomic(1)
cDNA(4)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR006055 |
Exonuclease |
| IPR012337 |
Polynucleotidyl transferase, ribonuclease H fold |
| IPR013520 |
Exonuclease, RNase T/DNA polymerase III |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:56273
Mazur DJ et al.,
"Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases."
J Biol Chem 1999 Jul 9;274(28):19655-60
(Latest)
J:151766
Parra D et al.,
"Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice."
Cancer Res 2009 Aug 15;69(16):6676-84
|
All references(4)
|
Analysis Tools
MGI BioMart