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Akt3 Gene Detail
 Symbol
Name
ID
Akt3
thymoma viral proto-oncogene 3
MGI:1345147


Nomenclature History
Synonyms D930002M15Rik, PKB gamma
Genetic Map
Chromosome 1
cytoband H4-H6
 
Mapping data( 3)
Sequence Map
Chr1:178950204-179188334 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: RAC serine/threonine-protein kinase
TreeFam: TF102004
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020798 VEGA Gene Model | MGI Sequence Detail 238131 C57BL/6J ± Kb
transcript NM_011785 RefSeq | MGI Sequence Detail 4735 C57BL/6
polypeptide Q9WUA6 UniProt | EBI | MGI Sequence Detail 479 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(3)
Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain.
Polymorphisms SNPs within 2kb(605 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular response to insulin stimulus, peptidyl-serine phosphorylation...
Component cytoplasm, membrane...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Assays (3)    Results (26)    Tissues (19)
Theiler Stages: 19,20,28
  Assay Type Assays   Results
      Western blot 2   19
      Immunohistochemistry 1   7
cDNA source data(5)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(6) cDNA(6) Antibodies(3)
Microarray probesets(3)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000019699
Consensus CDS Project CCDS35799.1
DFCI TC1584148, TC1629839
NIA Mouse Gene Index U022116
Entrez Gene 23797
VEGA Gene Model OTTMUSG00000020798
International Mouse Knockout Project Status Akt3
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR001849 Pleckstrin homology
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR011993 Pleckstrin homology-type
IPR015744 Rac serine/threonine kinase
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR017892 Protein kinase, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:54026 Brodbeck D et al., "A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain." J Biol Chem 1999 Apr 2;274(14):9133-6
(Latest) J:156391 Buzzi F et al., "Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass." Mol Cell Biol 2010 Feb;30(3):601-12
All references(30)
Other
accession IDs
MGI:2138357

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory